Results 81 to 90 of about 15,521,488 (377)

LSTM: A Search Space Odyssey [PDF]

IEEE Transactions on Neural Networks and Learning Systems, 2015
Several variants of the long short-term memory (LSTM) architecture for recurrent neural networks have been proposed since its inception in 1995. In recent years, these networks have become the state-of-the-art models for a variety of machine learning ...
Klaus Greff, R. Srivastava, Jan Koutník, Bas R. Steunebrink, J. Schmidhuber   +4 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PDE-Constrained Scale Optimization Selection for Feature Detection in Remote Sensing Image Matching

Mathematics
Feature detection and matching is the key technique for remote sensing image processing and related applications. In this paper, a PDE-constrained optimization model is proposed to determine the scale levels advantageous for feature detection. A variance
Yunchao Peng, Bin Zhou, Feng Qi
doaj   +1 more source

Scale invariant Einstein-Cartan gravity and flat space conformal symmetry

Journal of High Energy Physics, 2023
We find the conditions under which scale-invariant Einstein-Cartan gravity with scalar matter fields leads to an approximate conformal invariance of the flat space particle theory up to energies of the order of the Planck mass.
Georgios K. Karananas, Mikhail Shaposhnikov, Sebastian Zell   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A high-resolution lithospheric magnetic field model of China and surroundings by using CHAMP, Swarm, CSES-1, and MSS-1 satellite magnetic measurements and aeromagnetic anomaly data

Earth and Planetary Physics
The CUG_CLMFM3D series comprises high-resolution three-dimensional lithospheric magnetic field models for China and its surroundings. The first version, CUG_CLMFM3Dv1, is a spherical cap harmonic model integrating the WDMAMv2 (World Digital Magnetic ...
Pan Zhang, JinSong Du, Liang Yin, Qing Yan, JiaXuan Zhang, HouPu Li, Keke Zhang, Chao Chen   +7 more
doaj   +1 more source

Computing an Exact Gaussian Scale-Space

Image Processing On Line, 2016
Gaussian convolution is one of the most important algorithms in image processing. The present work focuses on the computation of the Gaussian scale-space, a family of increasingly blurred images, responsible, among other things, for the scale-invariance ...
Ives Rey Otero, Mauricio Delbracio
doaj   +1 more source

Scale Anomalies, States, and Rates in Conformal Field Theory

, 2016
This paper presents two methods to compute scale anomaly coefficients in conformal field theories (CFTs), such as the c anomaly in four dimensions, in terms of the CFT data.
Gillioz, Marc, Lu, Xiaochuan, Luty, Markus A.   +2 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source