Results 171 to 180 of about 1,999,506 (317)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Comparing Likert and visual analogue scales in ecological momentary assessment. [PDF]

Behav Res Methods
Haslbeck JMB, Martínez AJ, Roefs AJ, Fried EI, Lemmens LHJM, Groot E, Edelsbrunner PA.   +6 more
europepmc   +1 more source

XX. On a new register-pyrometer, for measuring the expansions of solids, and determining the higher degrees of temperature upon the common thermometric scale [PDF]

J. Frederic Daniell
openalex   +1 more source

Constructing a Language and Grammar Scale [PDF]

, 1920
W. W. Charters
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Investigating health literacy and sociodemographic factors in college students. [PDF]

Sci Rep
Sudhakar SK, Doshi DP, Nair G, Rao T.
europepmc   +1 more source

The Beaufort Scale [PDF]

, 1959
E. L. Delmar-Morgan
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Novel tools for comparing the architecture of psychopathology between neurogenetic disorders: An application to X- versus Y-chromosome aneuploidy effects in males. [PDF]

Psychol Med
Larsen IG, Liu S, Schaffer L, Rau S, Ajumobi T, Mahony BW, Warling A, Whitman ET, Nadig A, McDermott C, Xenophontos A, Wilson K, Clasen LS, Torres EN, Blumenthal JD, Bassett DS, Raznahan A.   +16 more
europepmc   +1 more source

THE NASH SCALE FOR MEASURING TREE CROWN WIDTHS [PDF]

, 1948
Andrew J. Nash
openalex   +1 more source