Results 91 to 100 of about 725,030 (319)

Towards a Common Language for Mainstreaming Nature-Based Solutions Through Coastal Systems in the North Sea Region: The Manabas Coast Project

Journal of Marine Science and Engineering
Nature-based solutions (NBSs) offer an opportunity to address environmental and societal challenges worldwide while simultaneously providing benefits for human well-being as well as biodiversity.
Geert J. M. van der Meulen, Jurre J. de Vries, Lisa van Well, Frances A. Kannekens   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Scaling of fracture response in Over-height Compact Tension tests [PDF]

, 2015
An experimental investigation into in-plane scaled Over-height Compact Tension (OCT) [45/90/-45/0]4s carbon/epoxy laminates was carried out to study the scaling of fracture response.
Hallett, Stephen R., Wisnom, Michael R., Mahadik, Yusuf, Xu, Xiaodong   +3 more
core   +1 more source

Working together to scale ecosystem restoration: collective approaches to community action in Aotearoa New Zealand

Ecology and Society
Community groups are key drivers of ecosystem restoration in many countries. However, there is increasingly recognition that small scale restoration efforts are often insufficient to reverse ongoing biodiversity declines, and questions have been raised ...
Kiely McFarlane, Kiri Joy Wallace, Danielle F Shanahan, Joanne E Clapcott   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation

eLife
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.
Carlos Gonzalez-Islas, Zahraa Sabra, Ming-fai Fong, Pernille Yilmam, Nicholas Au Yong, Kathrin Engisch, Peter Wenner   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Abnormal cortical development after premature birth shown by altered allometric scaling of brain growth. [PDF]

, 2006
BACKGROUND: We postulated that during ontogenesis cortical surface area and cerebral volume are related by a scaling law whose exponent gives a quantitative measure of cortical development.
Ajayi-Obe, M., Nadeem Saeed, Allsop, J. M., Boardman, J., Kennea, N, Morenike Ajayi-Obe, Dyet, L., Jaroslav Stark, Frances Cowan, Saeed Nadeem, Philip Duggan, Allsop Joanna M, Counsell, S. J.; id_orcid, Kennea, N., Ajayi-Obe Morenike, Stark, J., Edwards, AD, Cowan, F, Mary A Rutherford, Joanna M Allsop, Dyet Leigh, Counsell Serena J, Counsell, SJ, Stark, J, Kennea Nigel, Duggan Philip, Maalouf, E, Allsop, JM, Kapellou, O, Jo Hajnal, Leigh Dyet, Rutherford, M. A., Rutherford, MA, Duggan, P., Edwards, A. D.; id_orcid, Ajayi-Obe, M, Maalouf Elia, A David Edwards, Maalouf, E., Boardman James, Cowan, F., Hajnal, J.; id_orcid, Saeed, N, Dyet, L, James Boardman, Cowan Frances, Edwards A. David, Duggan, P, Rutherford Mary A, Hajnal Jo, Elia Maalouf, Olga Kapellou, Kapellou, O., Serena J Counsell, Saeed, N., Hajnal, J, Stark Jaroslav, Boardman, J, Nigel Kennea, Kapellou Olga   +59 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source