Results 141 to 150 of about 725,030 (319)
Long-term memories of developed and emerging markets: Using the scaling analysis to characterize their stage of development [PDF]
The scaling properties encompass in a simple analysis many of the volatility characteristics of financial markets. That is why we use them to probe the different degree of markets development.
T. Di Matteo +2 more
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Preferential Behaviour and Scaling in Diffusive Dynamics on Networks
, 2007 We study the fluctuation properties and return-time statistics on inhomogeneous scale-free networks using packets moving with two different dynamical rules; random diffusion and locally navigated diffusive motion with preferred edges.
Kujawski, B, Tadic, B, Rodgers, GJ
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
To control or not control: A coordination perspective to scaling [PDF]
Over the past few years, the question of how social enterprises can effectively scale their impact to reach people and communities has received increasing attention from various parties such as policy makers, governments, various organizational leaders ...
Mair, Johanna, Sezgi, Funda
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Multidimensional Scaling Using Majorization: SMACOF in R
In this paper we present the methodology of multidimensional scaling problems (MDS) solved by means of the majorization algorithm. The objective function to be minimized is known as stress and functions which majorize stress are elaborated. This strategy
Patrick Mair, Jan de Leeuw
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
3WaySym-Scal: three-way symbolic multidimensional scaling
Multidimensional scaling aims at reconstructing dissimilarities between pairs of objects by distances in a low dimensional space.However, in some cases the dissimilarity itself is not known, but the range, or a histogram of the dissimilarities is given ...
Groenen, P.J.F., Winsberg, S.
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