Results 181 to 190 of about 837,890 (213)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Population Pharmacokinetics and Extrapolation of NP-011 from Animal to Humans: A Novel Therapeutic Candidate Protein for Metabolic Dysfunction-Associated Steatohepatitis. [PDF]

Pharmaceutics
Lee H, Tran QT, Tham BT, Kim MK, Yun HY, Chae JW, Park JH, Lee S.   +7 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Escaping the Scaling Relationships in Oxygen Reduction Catalysis: Implications for PEM Fuel Cells. [PDF]

Adv Mater
Wazir MB, Vega LF, Khaleel M.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Exact Solution of the Glauber-Ising Model on the Finite-Length Semi-Open Chain. [PDF]

Entropy (Basel)
Henkel M.
europepmc   +1 more source

A cloud-native framework for seismic waveform data quality assessment: Performance evaluation under equivalent resource constraints. [PDF]

PLoS One
Li Y, Wang D, Dong R, Cheng C, Zhang X, Wang W, Liu C.   +6 more
europepmc   +1 more source

Cognitive Processes of Probabilistic Prediction in Reading: Language Model Surprisal Across Model Sizes, Token Granularity, and Reading Paradigms. [PDF]

J Intell
Liu S, Mei Y.
europepmc   +1 more source

Moment-Equivalent Adhesion Statistics Inferred From Particle Resuspension Kinetics. [PDF]

Small Sci
Almog R, Klausner Z, Berkovich R.
europepmc   +1 more source