Results 211 to 220 of about 9,149,613 (368)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Crossing Scales and Disciplines to Achieve Forest Sustainability

Ecology and Society, 2008
Michael J. Papaik, Brian Sturtevant, Christian Messier   +2 more
doaj   +1 more source

Molecular diversity of dissolved organic matter reflects macroecological patterns in river networks. [PDF]

Sci Rep
Freeman EC, Mudunuru MK, Feeser KL, McClure EA, González-Pinzón R, Ward CS, Bottos EM, Krause S, Peña J, Newcomer ME.   +9 more
europepmc   +1 more source

LARGE SCALE SYNTHESIS AND PURIFICATION OF FLAVIN ADENINE DINUCLEOTIDE

, 1956
Chester DeLuca, Nathan O. Kaplan
openalex   +1 more source

A critique of the Yerkes-Bridges Hardwick comparison of the Binet-Simon and Point scales. [PDF]

, 1917
Frank N. Freeman
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

GeoMIP-Pattern - a pattern scaling dataset for efficient generation of custom geoengineering scenarios. [PDF]

Sci Data
Muñoz-Sánchez R, Bastien-Olvera BA, Calderón O, Estrada Porrúa F, Altamirano M.   +4 more
europepmc   +1 more source

Winterkilling of the San José Scale [PDF]

, 1920
Anthony Spuler
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

An integrated model of threshold-based scaling and fractional admission controlling to improve resource utilization efficiency in 5G core networks. [PDF]

PLoS One
Hoa LC, Dang TC, Vo VMN.
europepmc   +1 more source