Results 321 to 330 of about 3,449,394 (355)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Rising atmospheric moisture escalates the future impact of atmospheric rivers in the Antarctic climate system. [PDF]

Commun Earth Environ
Maclennan ML, Winters AC, Shields CA, Thaker R, Barthelemy L, Codron F, Wille JD.   +6 more
europepmc   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Utilizing Molecular Descriptor Importance to Enhance Endpoint Predictions. [PDF]

Toxics
Bajželj B, Novič M, Drgan V.
europepmc   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Chain Size and Knots of Ring Polymers in All-Crossing and Intra-Crossing Melts. [PDF]

Polymers (Basel)
Mo J, Guo J, Yu X, Yang J, Hu G, Xin J, Yan M, Wang Y, Mo Y, Jia Y, Wu L, Ruan Y.   +11 more
europepmc   +1 more source

No compromise in efficiency from the co-application of a marine and a terrestrial CDR method. [PDF]

Nat Commun
Moustakis Y, Wey HW, Nützel T, Oschlies A, Pongratz J.   +4 more
europepmc   +1 more source

Pan-cancer predictive survival model development and evaluation using electronic health record and genetic data across 10 cancer types. [PDF]

Discov Oncol
Gammall J, Lai AG.
europepmc   +1 more source

The spatiotemporal scaling laws of urban population dynamics. [PDF]

Nat Commun
Tan X, Huang B, Batty M, Li W, Wang QR, Zhou Y, Gong P.   +6 more
europepmc   +1 more source