Results 81 to 90 of about 142,017 (273)

Improved approximation algorithm for k-level UFL with penalties, a simplistic view on randomizing the scaling parameter

, 2013
The state of the art in approximation algorithms for facility location problems are complicated combinations of various techniques. In particular, the currently best 1.488-approximation algorithm for the uncapacitated facility location (UFL) problem by ...
A. Ageev, F. Chudak, G. Xu, G. Xu, J. Byrka, J. Byrka, J. Geunes, J. Zhang, K. Aardal, K. Jain, M.I. Sviridenko, S. Guha, S. Li, Y. Li   +13 more
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Aggregation and long memory: recent developments [PDF]

, 2013
It is well-known that the aggregated time series might have very different properties from those of the individual series, in particular, long memory.
Leipus, Remigijus, Philippe, Anne, Puplinskaite, Donata, Surgailis, Donatas   +3 more
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Studying cities to learn about minds: some possible implications of space syntax for spatial cognition [PDF]

, 2009
What can we learn of the human mind by examining its products? The city is a case in point. Since the beginning of cities human ideas about them have been dominated by geometric ideas, and the real history of cities has always oscillated between the ...
Hillier, B
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Comparison of the efficacy of chlorhexidine varnish and chip in the treatment of chronic periodontitis

Contemporary Clinical Dentistry, 2013
Background: The purpose of this study was to clinically evaluate the benefits of sub gingival chlorhexidine (CHX) varnish and biodegradable CHX chip application used as an adjunct to scaling and root planning (SRP) as combined therapy and also to compare
B S Jagadish Pai, Smitha Anitha Rajan, M Srinivas, R Padma, Girish Suragimath, Amit Walvekar, Saakshi Goel, Vinesh Kamath   +7 more
doaj   +1 more source

ExpandED Schools National Demonstration: Lessons for Scale and Sustainability [PDF]

, 2016
Can schools and community organizations come together to provide children with critical enrichment activities that enhance knowledge and expand horizons beyond core academics during the school day?
Christina A. Russell, Jeanine L. Hildreth, Pamela Stevens   +2 more
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Modulatory effects by neodymium-doped yttrium aluminum garnet laser on fibroblast attachment to single rooted tooth surfaces following ultrasonic scaling and root planning: An in vitro study

Journal of Indian Society of Periodontology, 2015
Context: One of the most important goals of periodontal therapy is connective tissue reattachment to previously diseased root surfaces. In the recent years, laser therapy has been considered as an important tool in improving the treatment of periodontal ...
Shanta Negi, Malathi Krishnamurthy, Kiran Kumar Ganji, Sunil Pendor   +3 more
doaj   +1 more source