Results 231 to 240 of about 102,318 (263)

The thermodynamic opportunities hypothesis: Metabolic temperature insensitivity across flatfish species. [PDF]

Sci Adv
Seibel BA.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Scaling and quantization of large-scale foundation model enables resource-efficient predictions in network biology. [PDF]

Nat Comput Sci
Chen H, Venkatesh MS, Gόmez Ortega J, Mahesh SV, Nandi TN, Madduri RK, Pelka K, Theodoris CV.   +7 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Good to excellent reliability of instrumented ankle passive resistance and strength measurements in children. [PDF]

Front Pediatr
Åhblom A, Duan Z, Destro A, Pontén E, Lidbeck C, Wang R.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

The Evolution of Lithography: From Resolution Scaling to Manufacturing Constraints. [PDF]

Micromachines (Basel)
Chae H, Park H, Kang DJ.
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Atmospheric stability sets maximum moist heat and convection in the midlatitudes. [PDF]

Sci Adv
Li F, Tamarin-Brodsky T.
europepmc   +1 more source

Effects of Ultrasonic Scaling and Teeth Brushing on Surface Properties of PEEK Prosthetic Restorations. [PDF]

Dent J (Basel)
Čairović AD, Perić MM, Čairović N, Župac L, Maksimović VM, Stevanović SS, Špadijer-Gostović AB, Stanimirović DM.   +7 more
europepmc   +1 more source