Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Scale Up, Small-scale Feasibility Studies, Tests and Testing [PDF]
Journal of Chemical Engineering & Process Technology, 2016 Kurt Miklia, James Creek
openaire +1 more source
Estimation of IDF curves of extreme rainfall by simple scaling in Slovakia
Contributions to Geophysics and Geodesy, 2009 Scaling properties of the short term extreme rainfall has not been investigated so far in Slovakia. In this study the simple scaling theory is applied to the intensity- duration-frequency (IDF) characteristics of short duration rainfall.
Márta BARA +4 more
doaj
A Pilot-Scale Gasifier Freeboard Equipped with Catalytic Filter Candles for Particulate Abatement and Tar Conversion: 3D-CFD Simulations and Experimental Tests [PDF]
Alessandra Tacconi +4 more
openalex +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
A Fast and Accurate Process Variation-aware Modeling Technique for Resistive Bridge Defects
Recent research has shown that tests generated without taking process variation into account may lead to loss of test quality. At present there is no efficient device-level modeling technique that models the effect of process variation on resistive ...
Khursheed, Saqib +2 more
core
ON SCALING OF BRAKE TEST SAE J2522
, 2020 Friction brakes represent the most important safety feature literally in all vehicles and their rigorous “friction testing” is usually performed on several platforms/scales and completed with field tests. Since friction and wear are system properties, it
McKavanagh, David Sean
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Passage-Dependent Size Distributions of Human-Derived Cells: Implications for Metabolic Assays. [PDF]
FASEB JBotte E +3 more
europepmc +1 more source