Results 261 to 270 of about 339,768 (366)

Position-dependent feedback drives scaling and robustness of morphogen gradients. [PDF]

Proc Natl Acad Sci U S A
Mosby LS, Hadjivasiliou Z.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Fault Tolerance Techniques for Hybrid CMOS/Nano Architecture

We propose two fault tolerance techniques for hybrid CMOS/nano architecture implementing logic functions as Look-Up Tables. We compare the efficiency of the proposed techniques with recently reported methods that use single coding schemes in tolerating ...
Srivastava, Saket, Melouki, Aissa, Al-Hashimi, Bashir   +2 more
core  

Dermoscopic Features of Tinea Capitis in Korean Patients: Correlation With Clinical Subtypes, Age Groups and Causative Dermatophytes. [PDF]

Mycoses
Tran TQT, Kim G, Ryu HJ, Park SK, Nam KH, Yun SK, Yoo H, Park J.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Neural temporal scaling accounts for robust hunting behavior across temperatures. [PDF]

Nat Commun
Tishby Tamari S, Rubinstein Y, Livneh N, Moshkovitz M, Karmi A, Avitan L.   +5 more
europepmc   +1 more source

Testing the classroom citizenship behaviors scale: exploring the association of classroom citizenship behaviors and student traits

, 2016
James A. Katt, Ann Neville Miller, Tim Brown   +2 more
openalex   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Sex- and Male-Morph-Specific Variation in Brain Mass and Cell Number Scaling in Solitary Centris pallida (Hymenoptera: Apidae) Bees. [PDF]

J Comp Neurol
Barrett M, Godfrey RK.
europepmc   +1 more source

Identifying Learning Patterns in the Upper-Intermediate Level of English Through Large-Scale Testing

, 2015
Irina Argüelles-Alvarez, Margarita Martínez   +1 more
openalex   +1 more source