Results 141 to 150 of about 14,169,777 (290)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Scaling up capacity of stand-alone adsorption refrigeration tubes

Results in Engineering, 2019
On the basis of a validated model, a parametric study is conducted to understand the effects of operating parameters on the coefficient of performance (COP) and specific cooling power (SCP) of a stand-alone adsorption refrigeration tube (ART).
Ersong Chen, Xiaoquan Wu, Yongling Zhao, Eric Hu, Juan F. Torres   +4 more
doaj  

On the Strength of Racks for Jack-up Units : 3rd Report: On Plastic Deformation and Fracture Behavior of a Full Scale Rack with a Back-Plate during Static Loading Test

, 1985
Hiroshi Honda
openalex   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Scaling Up Single-Cell Proteomics

Molecular & Cellular Proteomics, 2021
N. Slavov
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Scaling up drug combination surface prediction. [PDF]

Brief Bioinform
Huusari R, Wang T, Szedmak S, Dias D, Aittokallio T, Rousu J.   +5 more
europepmc   +1 more source

On the strength of racks for jack-up units. 4th report Estimation of the static strength of the racks, by using small scale specimens, for the meshings in the vicinity of rack tooth tip and fillet.

, 1985
Hiroshi Honda, Naoyuki Koga, Katsuyoshi Abe, Toshinobu SHIBATA   +3 more
openalex   +2 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Value of a Nationwide University Network in scaling up telemonitoring: a qualitative study. [PDF]

BMJ Health Care Inform
Gijsbers HJH, Nurmohamed SA, Dusseljee-Peute LW, Schijven MP, van de Belt TH, Citrien 2.   +5 more
europepmc   +1 more source