Results 161 to 170 of about 1,653,695 (312)

Scaling up evidence-based public health training [PDF]

, 2018
Allen, Peg, Bass, Kathryn, Brownson, Carol A, Brownson, Ross, Yang, Samuel C   +4 more
core   +1 more source

Norms for scaling up small and sick newborn care: an overview of reviews. [PDF]

J Glob Health
Strobel NA, Whisson G, Swe D, Budrikis A, Edmond KM.   +4 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Identifying priority countries for scaling up small-quantity lipid-based nutrient supplements. [PDF]

BMJ Glob Health
Noori N, Stewart CP, McDonald CM, Wessells KR, Root ED, Dewey KG.   +5 more
europepmc   +1 more source

16 Successful scale up and spread of transformational outcomes to reduce cost and bring joy every day [PDF]

Nasser Al Naimi, Reham Negmeldin, Maryanne Gillies   +2 more
openalex   +1 more source

Scaling up community-based cervical cancer screening in Cameroon employing a single visit approach [PDF]

, 2020
Damien Grohar, Pierre Vassilakos, Khadidja Benkortbi, Evelyn Tincho, Bruno Kenfack, Patrick Petignat   +5 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Scaling up for end-to-end on-chip photonic neural network inference. [PDF]

Light Sci Appl
Wu B, Huang C, Zhang J, Zhou H, Wang Y, Dong J, Zhang X.   +6 more
europepmc   +1 more source