Results 221 to 230 of about 14,169,777 (290)

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Ultrastructure and cardiac impulse propagation: scaling up from microscopic to macroscopic conduction. [PDF]

J Physiol
Qu Z, Hanna P, Ajijola OA, Garfinkel A, Shivkumar K.   +4 more
europepmc   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Where Biology Meets Engineering: Scaling Up Microbial Nutraceuticals to Bridge Nutrition, Therapeutics, and Global Impact. [PDF]

Microorganisms
Elazzazy AM, Baeshen MN, Alasmi KM, Alqurashi SI, Desouky SE, Khattab SMR.   +5 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

A Cross-Disciplinary Analysis of the Complexities of Scaling Up eHealth Innovation.

J Med Internet Res
Allers S, Carboni C, Eijkenaar F, Wehrens R.   +3 more
europepmc   +1 more source

Scaling up! Staff e-learning for a national take-home naloxone program. [PDF]

Front Digit Health
Ericson ØB, Eide D, Brendryen H, Lobmaier P, Clausen T.   +4 more
europepmc   +1 more source

Scale-Up of Advanced Hot-Gas desulfurization Sorbents.

, 1997
K. Jothimurugesan, S.K. Gangwal
openalex   +2 more sources

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Half-decade of scaling up malaria control: malaria trends and impact of interventions from 2018 to 2023 in Rwanda. [PDF]

Malar J
Umugwaneza A, Mutsaers M, Ngabonziza JCS, Kattenberg JH, Uwimana A, Ahmed A, Remera E, Kubahoniyesu T, Nsanzabaganwa C, Mugabo H, Rukundo G, Kabera M, Mbituyumuremyi A, Hakizimana E, Muvunyi CM, Rosanas-Urgell A.   +15 more
europepmc   +1 more source