Results 71 to 80 of about 76,707 (260)

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects

Advanced Science, EarlyView.
Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song, Zhewei Shuai, Weiyan Sun, Liang Chen, Yiwei Shen, Jiateng Hu, Yuanqi Ma, Jie Luo, Meilin Huang, Yan Luo, Yunlang She, Guangdong Zhou, Chang Chen, Dong Lei   +13 more
wiley   +1 more source

Comparative evaluation of gingival depigmentation by tetrafluroethane cryosurgery and surgical scalpel technique. A randomized clinical study

Contemporary Clinical Dentistry, 2017
Introduction: Importance of good smile cannot be underestimated in enhancement of beauty, self-confidence and personality of a person. Health and appearance of gingiva is an essential part of attractive smile.
Suraj D Narayankar, Neeraj C Deshpande, Deepak H Dave, Dhaval J Thakkar   +3 more
doaj   +1 more source

Gingival depigmentation using two different approaches – Case reports

Journal of Dr. NTR University of Health Sciences
Gingival hyperpigmentation is a major esthetic concern among young individuals. Various treatment approaches for depigmentation include scalpel, burs, lasers, etc., The present case report illustrates depigmentation using a laser and a scalpel with 180 ...
Neha Singh
doaj   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Quantification of transcript isoforms at the single-cell level using SCALPEL

Nature Communications
Single-cell RNA sequencing (scRNA-seq) facilitates the study of transcriptome diversity in individual cells. Yet, many existing methods lack sensitivity and accuracy.
Franz Ake, Marcel Schilling, Sandra M. Fernández-Moya, Akshay Jaya Ganesh, Ana Gutiérrez-Franco, Lei Li, Mireya Plass   +6 more
doaj   +1 more source

A Comparative Study Between Harmonic Scalpel and Classical Knot Tying in Total Thyroidectomy [PDF]

Kirkuk Journal of Medical Sciences
Background: Total thyroidectomy is the most common endocrine surgery performed in hospitals worldwide. Thyroidgland is a highly vascularized structure and has a rich supply therefore; delicate techniques must be used in its excision.Classical techniques ...
Ali Ameen, Hussein Ahmed
doaj   +1 more source

Phase‐Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar‐Reduced Regeneration of Burn Wounds

Advanced Science, EarlyView.
A phase‐programmed microneedle patch, comprising a poly (lactic‐co‐glycolic acid) (PLGA) shell and a sulfobutylether‐β‐cyclodextrin (SBECD) core, is designed for sequential hydrogen and quercetin release for scar‐reduced regeneration of burn wounds. ABSTRACT Burn wounds complicated by bacterial infection and fibrotic scarring remain a major clinical ...
Yongnian Zeng, Zhigang Chu, Huiyuan Yang, Wen Zhang, Peng Jiang, Jiapeng Lei, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source

Histopathologic Comparison of Radiofrequency and Scalpel Blade on Mice Skin Incisional Wound Healing Model [PDF]

Pakistan Veterinary Journal, 2012
Using a safe and accurate alternative to scalpel blades for various surgical operations has been more considering today. There are many studies about the healing process of various tissues after using different methods like radiofrequency, electro ...
Banafshe Gholamhoseini*, Soroush Mohitmafi1, Payam Razeghi Tehrani2 and Sattar Noorialeagha3
doaj  

Hybrid Two‐Step Inkjet Printing and Dip‐Coating Enable Scalable 30%‐Efficient Perovskite/Silicon Tandem Solar Cells

Advanced Energy Materials, EarlyView.
Adopting a scalable hybrid two‐step deposition process route, textured perovskite/silicon tandem solar cells achieve over 30% power‐conversion efficiency. The process route replaces all non‐scalable spin‐coating steps, including organic precursor deposition, self‐assembled monolayer formation, and passivation layer deposition, with scalable techniques ...
Raphael Pesch, Lena P. Rothbauer, Johannes Schenk, Lingyi Fang, Theresa Kuechle, Julian Petry, Uma K. Dangudubiyyam, Richard Thelen, David B. Ritzer, Ting Pan, Daniel O. Baumann, Mohammad Gholipoor, Tonghan Zhao, Nils W. Rosemann, Jinzhao Li, Ulrich Lemmer, Ulrich W. Paetzold   +16 more
wiley   +1 more source