Results 71 to 80 of about 2,619,148 (295)
Two Cases of Nivolumab Re-Administration after Pneumonitis as Immune-Related Adverse Events
Case Reports in Oncology, 2017 Nivolumab is a recently approved medication for the treatment of unresectable malignant melanoma. Many immune-related adverse events (irAEs) associated with nivolumab have been reported, such as pneumonitis, hepatitis, dermatitis, and thyroiditis ...
Keisuke Imafuku +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Texas Pattern Jury Charges [PDF]
, 2011 Guide listing pattern jury charges to assist the bench and bar in preparing the court's charge for the jury in the state of Texas, including general instructions for the guilt/innocence and punishment stages of the trial, and instructions related to ...
State Bar of Texas. Committee on Pattern Jury Charges. +1 more
core
A case of retinopathy of prematurity treated by pattern scan laser photocoagulation
Clinical Ophthalmology, 2014 Satoshi Ota, Miho Nozaki, Shuichiro Hirahara, Tomoaki Hattori, Munenori Yoshida, Yuichiro Ogura Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Abstract: We experienced a case of
Ota S +5 more
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Optimal Scanning Pattern for Initial Free-Space Optical-Link Alignment
PhotonicsSince free-space optical links (especially fully photonic ones) are very challenging to accurately align; scanning algorithms are used for the initial search and alignment of the transceivers.
Petr Skryja, Peter Barcik
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 1934 Envelope for a McCall Kaumagraph Transfer pattern to make appliqué tulip flower and flower pot designs for suggested items such as kitchen curtains, table runners and pot holders; includes illustrations of finished pieces and instructions for ...
McCall Pattern Company
core