Results 71 to 80 of about 393,105 (264)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Low-power design-for-test implementation on phase-locked loop design

Measurement + Control, 2019
Low-power design for test is the need of the hour for any system-on-chip designer. The low-power design techniques have been a major challenge to both the designer as well as the testing engineer.
Avinash Yadlapati, Hari Kishore Kakarla
doaj   +1 more source

Dome-Shaped Macula versus Ridge-Shaped Macula Eyes in High Myopia Based on the 12-line Radial Optical Coherence Tomography Scan Pattern. Differences in Clinical Features. [PDF]

Diagnostics (Basel), 2021
García-Zamora M, Flores-Moreno I, Ruiz-Medrano J, Vega-González R, Puertas M, Almazán-Alonso E, González-Buendía L, Ruiz-Moreno JM.   +7 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Carotid duplex scanning: Patterns of referral and outcome

European Journal of Vascular and Endovascular Surgery, 1995
Review of the results of carotid Duplex scanning.Retrospective review of new referrals for carotid Duplex scanning to a regional vascular laboratory.1041 referrals made over an 18 month period.Referrals were reviewed for scan quality, diagnostic category and outcome of scanning.The overall detection rate of ipsilateral stenoses > 70% and occlusions was
Perkins, J.M.T., Collin, J., Walton, J., Hands, L.J., Morris, P.J.   +4 more
openaire   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Evaluating geometric accuracy of embroidered QR codes for smart tag applications

Journal of Engineered Fibers and Fabrics
Embroidery offers a durable and attractive option for textile smart tags, but the effect of embroidery parameters on QR code accuracy and readability is still mostly unexamined, even in earlier studies.
Breitmozere Inga, Domskiene Jurgita
doaj   +1 more source

Serous retinal detachment following panretinal photocoagulation (PRP) using Pattern Scan Laser (PASCAL) photocoagulator []

GMS Ophthalmology Cases, 2012
[english] Objective: To report a case of serous retinal detachment after Pattern Scan Laser (PASCAL) treatment in a diabetic woman. Methods: A 34-year-old diabetic woman presented with florid diabetic retinopathy after a miscarriage during the 20 week of
Azar, Georges, Wolff, Benjamin, Cornut, Pierre-Loïc, Mauget-Faÿsse, Martine   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Pattern of Doppler Ultrasonographic Scan Requests and Findings: A 3-Year Study

Annals of Health Research, 2016
Introduction: Doppler ultrasonography is a radiological investigative tool which is relatively new in developing countries, Nigeria inclusive.
Olatunji AA, Odusan O
doaj