Results 61 to 70 of about 1,136,335 (337)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
, 2009 Light scattering techniques are widely used in many fields of condensed and sof t matter physics. Usually these methods are based on the study of the scattered light in the far field.
A. P. Philipse +30 more
core +1 more source
\(C^{1}\) positive scattered data interpolation
Computers & Mathematics with Applications, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hussain, Malik Zawwar, Hussain, Maria
openaire +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
ArchEnemy: Removing scattered-light glitches from gravitational wave data [PDF]
, 2023 A. E. Tolley +3 more
openalex +1 more source
Mapping of interstellar clouds with infrared light scattered from dust: TMC-1N [PDF]
, 2013 Mapping of near-infrared (NIR) scattered light is a recent method for the study of interstellar clouds, complementing other, more commonly used methods, like dust emission and extinction. Our goal is to study the usability of this method on larger scale,
Juvela, M. +3 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Near-field imaging of locally perturbed periodic surfaces [PDF]
, 2019 This paper concerns the inverse scattering problem to reconstruct a locally perturbed periodic surface. Different from scattering problems with quasi-periodic incident fields and periodic surfaces, the scattered fields are no longer quasi-periodic.
Liu, Xiaoli, Zhang, Ruming
core +3 more sources
Norm-Minimized Scattering Data from Intensity Spectra [PDF]
Mathematical Problems in Engineering, 2016 We apply thel1minimizing technique of compressive sensing (CS) to nonlinear quadratic observations. For the example of coherent X-ray scattering we provide the formulas for a Kalman filter approach to quadratic CS and show how to reconstruct the scattering data from their spatial intensity distribution.
Alexander Seel +3 more
openaire +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source