Results 221 to 230 of about 34,826 (273)

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert   +13 more
wiley   +1 more source

In‐Tumor CRISPR‐Cas9 Knockout Screening and Novel Therapy Development for Malignant Transformation of Ovarian Teratoma

open access: yesCancer Science, EarlyView.
We conducted an in vivo genome‐wide CRISPR‐Cas9 knockout screen using MTMCT‐derived cells to identify genes essential for tumor growth. SOD1 emerged as a key therapeutic target, and its inhibition suppressed tumor proliferation by disrupting redox homeostasis, both in vitro and in PDX models. ABSTRACT Malignant transformation of mature cystic teratoma (
Satoshi Tamauchi   +8 more
wiley   +1 more source

Five-year change in sleep duration and incident Alzheimer's Disease and Related Dementias among lower-income older adults. [PDF]

open access: yesAlzheimers Dement
Shi H   +10 more
europepmc   +1 more source

Solid Shampoo Is Mostly Not Preserved, in Contrast to Liquid Shampoos Used in Hairdressing—A Market Survey in Four European Countries

open access: yesContact Dermatitis, EarlyView.
Most solid shampoos (68.6%) did not contain preservatives according to Annex V of the EU Cosmetics Regulation (EC 1223/2009), while all liquid shampoos did. The number of preservatives used was significantly greater in liquid shampoos. ABSTRACT Background Hairdressers are frequently exposed to shampoos, both from neat liquid products and dilutions ...
Wolfgang Uter   +7 more
wiley   +1 more source

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