Results 81 to 90 of about 34,826 (273)

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

A Granulation Strategy-Based Algorithm for Computing Strongly Connected Components in Parallel

Mathematics
Granular computing (GrC) is a methodology for reducing the complexity of problem solving and includes two basic aspects: granulation and granular-based computing. Strongly connected components (SCCs) are a significant subgraph structure in digraphs.
Huixing He, Taihua Xu, Jianjun Chen, Yun Cui, Jingjing Song   +4 more
doaj   +1 more source

The comparison of Architect SCC and cobas SCC tests

Diagnostyka Laboratoryjna, 2017
ntroduction: Squamous cell carcinoma antigen isolated by Kato and Torigoe in 1977, belonging to the serine and cysteine proteases inhibitors has been recognized as the marker of choice for the cervical cancer. However, high SCC expression has been also found in others neoplasms such as non-small cell lung cancer and head and neck carcinoma.<br> ...
Ewa Wójcik, Krzysztof Reinfuss, Zofia Stasik, Urszula Rychlik, Jadwiga Tarapacz, Jan K. Kulpa   +5 more
openaire   +1 more source

Crypto-Harmonic Oscillator in Higher Dimensions: Classical and Quantum Aspects

, 2008
We study complexified Harmonic Oscillator models in two and three dimensions. Our work is a generalization of the work of Smilga \cite{sm} who initiated the study of these Crypto-gauge invariant models that can be related to $PT$-symmetric models.
Bagchi B, Banerjee R, Bender C M, Bibhas Ranjan Majhi, Chand F, Curtright T Mezincescu L, Dirac P A M, Levai G, Scholtz F G, Smilga A V, Stuckelberg E C G, Subir Ghosh   +11 more
core   +1 more source

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of BiTE‐Secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Advanced Science, EarlyView.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho   +27 more
wiley   +1 more source

Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma

Frontiers in Oncology, 2020
Lung squamous cell carcinomas (SCCs) are highly aggressive tumors, and there is currently no effective targeted therapy owing to the lack of specific mutation targets.
Wenzheng Guo, Yanbin Kuang, Yanbin Kuang, Jingjing Wu, Donghua Wen, Aiping Zhou, Yueling Liao, Hongyong Song, Dongliang Xu, Tong Wang, Bo Jing, Kaimi Li, Min Hu, Jing Ling, Qi Wang, Wenjuan Wu   +15 more
doaj   +1 more source

A Full Characterization of Nash Implementation with Strategy Space Reduction [PDF]

Noting that a full characterization of Nash-implementation is given using a canonical-mechanism and Maskin’s theorem (Maskin, 1999) is shown using a mechanism with Saijo’s type of strategy space reduction (Saijo, 1988), this paper fully characterizes the
Lombardi, Michele, Yoshihara, Naoki
core  

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Convergence behaviour of structural FSM traversal [PDF]

, 2006
We present a theoretical analysis of structural FSM traversal, which is the basis for the sequential equivalence checking algorithm Record & Play presented earlier.
Kunz, Wolfgang, Stoffel, Dominik
core