Results 71 to 80 of about 1,294,914 (250)

Macroecology meets IPBES

Frontiers of Biogeography, 2016
The Intergovernmental Platform for Biodiversity and Ecosystem Services (IPBES), established in 2012 to counter the biodiversity crisis, requires the best scientific input available to function as a successful science-policy interface that addresses the ...
Christian Hof, D. Matthias Dehling, Aletta Bonn, Neil D. Burgess, Felix Eigenbrod, Michael B. J. Harfoot, Thomas Hickler, Walter Jetz, Elisabeth Marquard, Henrique M. Pereira, Katrin Böhning-Gaese   +10 more
doaj  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Moving Toward a Strategy for Addressing Climate Displacement of Marine Resources: A Proof-of-Concept

Frontiers in Marine Science, 2020
Realistic predictions of climate change effects on natural resources are central to adaptation policies that try to reduce these impacts. However, most current forecasting approaches do not incorporate species-specific, process-based biological ...
M. Cristina Mangano, Nova Mieszkowska, Nova Mieszkowska, Brian Helmuth, Tiago Domingos, Tania Sousa, Giuseppe Baiamonte, Giuseppe Bazan, Angela Cuttitta, Fabio Fiorentino, Antonio Giacoletti, Magnus Johnson, Giuseppe D. Lucido, Marco Marcelli, Marco Marcelli, Riccardo Martellucci, Riccardo Martellucci, Simone Mirto, Bernardo Patti, Fabio Pranovi, Gray A. Williams, Gianluca Sarà   +21 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Assessing scenarios on the future of work [PDF]

In this paper will be discussed different types of scenarios and the aims for using scenarios. Normaly they are being used by organisations due to the need to anticipate processes, to support policy-making and to understand the complexities of relations.
António Brandão Moniz
core  

Culture and climate change scenarios: The role and potential of the arts and humanities in responding to the ‘1.5 degrees target’ [PDF]

, 2018
This paper critically assesses the role and potential of the arts and humanities in relation to the ‘1.5 degree target’ embedded within the Paris Agreement.
Tyszczuk, R.A., Smith, J., Renata Tyszczuk, Tyszczuk, Renata, Joe Smith, Smith, Joe   +5 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Cutting and Pasting with Requirements Specifications Scenarios

Wireless Telecommunications requirements specifications tend to be defined as sets of normative scenarios. These frequently only provide partial coverage of the scenarios that are necessary to give a comprehensive specification.
Jervis, Clive, Mitchell, Bill, Bristow, Paul, Thomson, Robert   +3 more
core   +1 more source