Results 81 to 90 of about 2,643,930 (312)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
On Scenario Synchronization [PDF]
, 2010 In software development a system is often viewed by various models at different levels of abstraction. It is very difficult to maintain the consistency between them for both structural and behavioral semantics. This paper focuses on a formal foundation for presenting scenarios and reasoning the synchronization between them.
Duc-Hanh Dang +2 more
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Role of Transdisciplinary Research for Agricultural Climate Change Adaptation Strategies
Agronomy, 2018 While science widely acknowledges the necessity of climate change adaptation (CCA), concrete strategies for CCA by major land-use actor groups at a local level are largely missing.
Markus Schermer +6 more
doaj +1 more source
Conventional Methods in Housing Market Analysis: A Review of Literature
Baltic Journal of Real Estate Economics and Construction Management, 2020 Housing market analysis has witnessed considerable changes in recent decades, especially as a result of the complexity of human settlements and the dynamics of property market analytical techniques.
Bello Musa Zango +2 more
doaj +1 more source
Modeling Spatial Charging Demands Related to Electric Vehicles for Power Grid Planning Applications
ISPRS International Journal of Geo-Information, 2020 The electrification of the transport sector together with an increasing share of renewable energies has the potential to reduce CO2 emissions significantly. This transformation requires the rollout of charging infrastructure, which has an impact on power
Philip Gauglitz +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Uncertainty in ensembles of global biodiversity scenarios
Nature Communications, 2019 While there is a clear demand for scenarios that provide alternative states in biodiversity with respect to future emissions, a thorough analysis and communication of the associated uncertainties is still missing.
W. Thuiller +4 more
semanticscholar +1 more source