Results 51 to 60 of about 816,298 (267)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Food System Scenarios in Uncertain Futures: A Case Study on Long-Term Local Food System Planning in Revelstoke, Canada

Agriculture
Scenario planning is a potentially effective method for supporting long-term planning for sustainable and resilient food systems; however, scenario exercises are often limited by too much focus on a single preferred future, not accounting for uncertainty
Robert Newell, Colin Dring, Leslie King, Melissa Hemphill   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Design of an Efficient Model for Psychological Disease Analysis and Prediction Using Machine Learning and Genomic Data Samples

Big Data and Cognitive Computing
There is a rapid growth in mental disorders, thus leading to a pressing demand for more sophisticated diagnosis techniques. Clinical assessments and symptomatic analyses for traditional diagnostics suffer from subjectivity, delayed diagnosis, and ...
Alparthi Kumuda, Saroj Kumar Panigrahy
doaj   +1 more source

Critical thinking perspectives of undergraduate students

Advancements in Agricultural Development, 2020
Today’s learners need support in not only developing capacity for a global mindset, but also for thinking critically about the world. Employers are seeking graduates who can enter the workforce prepared to work within agriculture with the ability to ...
Nicole Stedman, Amy Brown
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Scenarios—using the complexity frame of reference to inform the construction of available futures in the possibility space

Frontiers in Complex Systems
The global socio-ecological system in the era of the Capitalocene—the world system created by the use of fossil fuels to provide energy for the development of a growth-oriented capitalist logic in all areas of production and consumption—is facing a set ...
David Sidney Byrne
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Scenario Modelling of University International Activities Based on Fuzzy Cognitive Maps

Proceedings of the International Conference on Applied Innovations in IT
In this article the concept of managing the effectiveness of international activities of universities based on fuzzy cognitive maps is discussed. The focus on the international relations currently plays an important role in almost all universities, as ...
Anastasia Krivtsun, Daria Kushchiy
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source