Results 61 to 70 of about 1,942,037 (303)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
The Role of Transdisciplinary Research for Agricultural Climate Change Adaptation Strategies
Agronomy, 2018 While science widely acknowledges the necessity of climate change adaptation (CCA), concrete strategies for CCA by major land-use actor groups at a local level are largely missing.
Markus Schermer +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 2019 The performance of TSO-DSO coordination schemes depends on the characteristics of the electricity systems in which regulation reserves can be provided by both transmission and distribution resources. In order to investigate the main aspects influencing TSO-DSO interactions, three detailed electricity scenarios (related to the expected 2030 evolution of
Rossi, Marco +6 more
openaire +3 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Investigating Integrated Approaches to Elderly Support for Tehrani Family in the Horizon of 1430 [PDF]
پژوهشنامه مددکاری اجتماعی, 2018 One of the important issues facing Tehrani families is the protection of the elderly. Future demographic, family, economic, and cultural changes will add to those more complex dimensions.
jafar hezajaribi +3 more
doaj +1 more source
ISS-Scenario: Scenario-Based Testing in CARLA
The rapidly evolving field of autonomous driving systems (ADSs) is full of promise. However, in order to fulfil these promises, ADSs need to be safe in all circumstances. This paper introduces ISS-Scenario, an autonomous driving testing framework in the paradigm of scenario-based testing.
Renjue Li +2 more
openaire +3 more sources
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Frontiers of Biogeography, 2016 The Intergovernmental Platform for Biodiversity and Ecosystem Services (IPBES), established in 2012 to counter the biodiversity crisis, requires the best scientific input available to function as a successful science-policy interface that addresses the ...
Christian Hof +10 more
doaj