Results 161 to 170 of about 1,680,593 (340)

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self‐Supervised Learning

open access: yesAdvanced Science, EarlyView.
CRCFound is a self‐supervised learning‐based CT image foundation model for colorectal cancer (CRC). Pretrained on 5137 unlabeled CRC CT images, it learns universal feature representations, enabling efficient adaptation to various clinical tasks. The model demonstrates outstanding performance and generalization across multiple diagnostic and prognosis ...
Jing Yang   +13 more
wiley   +1 more source

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells

open access: yesAdvanced Science, EarlyView.
ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li   +15 more
wiley   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

open access: yesAdvanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu   +10 more
wiley   +1 more source

Potentiating the Efficacy of mRNA Vaccines through NIR‐II Imaging‐Guided Precise Vaccination

open access: yesAdvanced Science, EarlyView.
A supramolecular strategy is utilized to integrate IR780‐C16 lipids into conventional LNPs, pioneering a novel NIR‐II‐LNPs platform that elucidates the correlations between mRNA vaccines efficacy and vaccination parameters in a non‐invasive approach.
Mengfei Li   +6 more
wiley   +1 more source

Impact of Revised Vaccination Recommendations for Mature Infants on Premature Infants' Vaccination Compliance in Germany. [PDF]

open access: yesInfect Dis Ther
Kühne F   +6 more
europepmc   +1 more source

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone‐Glucocorticoid Receptor‐LAMA5 Axis

open access: yesAdvanced Science, EarlyView.
In vivo experiments suggest that cardiomyocyte hypertrophy is an early manifestation of cardiac pathological changes induced by chronic psychological stress. In vivo and in vitro experiments suggest that the corticosterone‐glucocorticoid receptor‐LAMA5 axis mediates cardiomyocyte hypertrophy induced by chronic psychological stress. The clinical results
Chuanjing Zhang   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy