Results 201 to 210 of about 1,680,593 (340)

Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy

open access: yesAdvanced Science, EarlyView.
To solve the challenge of PROTACs in clinical potential due to poor water solubility and membrane permeability, a nanodelivery system based on lipid nanodisks loaded with MZ1 prodrug (LND‐MZ1) to remodel the physicochemical and pharmacokinetic properties of PROTAC MZ1 is elaborately proposed.
Meichen Pan   +6 more
wiley   +1 more source

A MXene‐Based Nanothermal Knife Inhibits Aggresome‐Mediated Persister Formation for Preventing Dental Caries

open access: yesAdvanced Science, EarlyView.
Early childhood caries (ECC) involves cariogenic persisters that evade antimicrobial treatment. Persisters achieve this by downregulating heat shock proteins (HSPs) and formation of protein aggregates. Ti3C2 MXene‐based photothermal therapy (PTT) acts as a “nanothermal knife,” disrupting membranes, upregulating HSPs, inhibits aggregates, prevents ...
Yinyin Zhang   +8 more
wiley   +1 more source

Determinants of polydipsia: IV. Free-reinforcement schedules [PDF]

open access: bronze, 1965
Evalyn F. Segal   +2 more
openalex   +1 more source

Harnessing the Immunomodulation of UV‐Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment

open access: yesAdvanced Science, EarlyView.
Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV‐irradiated keratinocytes.
Lu Liu   +16 more
wiley   +1 more source

Modulating light level patterns reduces rest/activity disruption associated with shiftwork. [PDF]

open access: yesNPJ Biol Timing Sleep
Mandi V   +8 more
europepmc   +1 more source

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