Results 221 to 230 of about 3,480,656 (399)

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

Advanced Science, EarlyView.
This study demonstrates that the resveratrol analogue, trans‐4,4′‐dihydroxystilbene (DHS), exhibits synergistic anti‐tumor activity with the PARP inhibitor talazoparib, inducing significant ovarian cancer cell death. The synergistic effect of this combination arises from the concurrent downregulation of homologous recombination factors and the ...
Ganesh Pai Bellare, Kshama Kundu, Papiya Dey, Krupa Thankam Philip, Nitish Chauhan, Muskan Sharma, Sankarsingh Kesharsingh Rajput, Birija Sankar Patro   +7 more
wiley   +1 more source

New Schedule [PDF]

, 1952

openalex   +1 more source

UniMap: Type‐Level Integration Enhances Biological Preservation and Interpretability in Single‐Cell Annotation

Advanced Science, EarlyView.
UniMap introduces a novel multiselective adversarial network that functions as a discerner in single‐cell dataset integration. It enables type‐level integration, ensuring accurate cell type annotation across diverse biological contexts while preserving shared and domain‐specific features.
Haitao Hu, Yue Guo, Fujing Ge, Hao Yin, Hao Zhang, Zhesheng Zhou, Fangjie Yan, Qing Ye, Jialu Wu, Ji Cao, Chang‐Yu Hsieh, Bo Yang   +11 more
wiley   +1 more source

The restoration potential of offshore mussel farming on degraded seabed habitat

Aquaculture, Fish and Fisheries, Volume 2, Issue 6, Page 437-449, December 2022., 2022
Due to the artificial structures that accumulate mussels and exclude destructive fishing practices, the seabed could be restored by the installation of mussel farming structure. After four years, there was a significantly greater abundance of mobile taxa compared to the Controls that remained open to trawling. Commercial European lobster and brown crab
Danielle Bridger, Martin J. Attrill, Bede F. R. Davies, Luke A. Holmes, Amy Cartwright, Siân E. Rees, Llucia Mascorda Cabre, Emma V. Sheehan   +7 more
wiley   +1 more source

Resurgence of Severe Challenging Behavior and Schedule Thinning with the Terminal Schedule Probe Method. [PDF]

Behav Sci (Basel)
Strohmeier CW, Thuman E, Falligant JM, Cengher M, Chin MD, Kurtz PF.   +5 more
europepmc   +1 more source

CK2B Induces CD8+ T‐Cell Exhaustion through HDAC8‐Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti‐PD‐1 Therapy in Non‐Small‐Cell Lung Cancer

Advanced Science, EarlyView.
αPD‐1 therapy has left an indelible mark in the field of NSCLC treatment; however, its efficacy is limited in clinical practice owing to the effector T‐cell exhaustion. These findings underscore CK2B as a promising target for overcoming the exhaustion of effector CD8+ T cells, thereby enhancing the efficacy of αPD‐1 and adoptive cell therapies in NSCLC.
Shaochuan Liu, Shiya Ma, Gen Liu, Lingjie Hou, Yong Guan, Liang Liu, Yuan Meng, Wenwen Yu, Ting Liu, Li Zhou, Zhiyong Yuan, Shuju Pang, Siyuan Zhang, Junyi Li, Xiubao Ren, Qian Sun   +15 more
wiley   +1 more source

Implications of holdfast availability and patchiness on juvenile seahorse (Hippocampus reidi) condition and welfare: Simulations in captivity

Aquaculture, Fish and Fisheries, Volume 2, Issue 6, Page 552-561, December 2022., 2022
Abstract Seahorses (Genus Hippocampus; Family Syngnathidae) are iconic fish characterised by tails with prehensile capabilities, which develop after the transition from planktonic to benthonic lifestyle. As a result, seahorses remain attached to vegetal structures or other elements most of the time, both in the wild and under rearing conditions. In the
Miquel Planas
wiley   +1 more source

Early-life gut microbiome associates with positive vaccine take and shedding in neonatal schedule of the human neonatal rotavirus vaccine RV3-BB. [PDF]

Nat Commun
Wagner J, Handley A, Donato CM, Lyons EA, Pavlic D, Ong DS, Bonnici R, Bogdanovic-Sakran N, Parker EPK, Bronowski C, Thobari JA, Satria CD, Nirwati H, Witte D, Jere KC, Mpakiza A, Watts E, Turner A, Boniface K, Mandolo J, Justice F, Bar-Zeev N, Iturriza-Gomara M, Buttery JP, Cunliffe NA, Soenarto Y, Bines JE.   +26 more
europepmc   +1 more source

Caspase‐6/Gasdermin C‐Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2‐Dependent Recruitment of Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
Hypoxic and low‐glucose conditions in tumor tissues trigger colorectal tumor cell pyroptosis via sequential activation of the Caspase‐1/Caspase‐6/GSDMC axis. High mobility group box 1 (HMGB1), released from GSDMC‐mediated pyroptotic tumor cells, upregulates CXCL2 expression in adjacent tumor cells, thereby recruiting myeloid‐derived suppressor cells ...
Hanchao Gao, Yikun Yao, Weilong Li, Zigan Xu, Wenjun Hu, Kewang Luo, Peishan Chen, Wanjing Shang, Shaodong Luan, Guojun Shi, Mengtao Cao, Pengfei Chen   +11 more
wiley   +1 more source

Replacing fallow with field pea in wheat production systems across western Nebraska

Agronomy Journal, Volume 114, Issue 6, Page 3329-3346, November/December 2022., 2022
Abstract Integration of field pea (Pisum sativum L.) (FP) into dryland cropping systems has increased due to ecological and economic benefits, paired with a growing market for pea‐derived products. Challenges exist in the High Plains that limit the integration of crop rotations to replace fallow periods with FP in wheat (Triticum aestivum L.)‐based ...
Samuel T. Koeshall, Amanda C. Easterly, Rodrigo Werle, Strahinja Stepanovic, Cody F. Creech   +4 more
wiley   +1 more source