Results 251 to 260 of about 1,680,593 (340)

Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top‐Down Middle Cingulate Amygdala Regulation and Brain‐Wide Fear Representations

Advanced Science, EarlyView.
This double‐blind, placebo‐controlled study demonstrates that intranasal oxytocin reduces subjective fear in immersive, naturalistic social (but not non‐social) contexts. Concomitant fMRI reveals that oxytocin enhances middle cingulate activity and amygdala connectivity while it modulates network‐level connectivity and attenuates reactivity of a brain ...
Kun Fu, Shuyue Xu, Zheng Zhang, Dan Liu, Ting Xu, Yuan Zhang, Feng Zhou, Xiaodong Zhang, Chunmei Lan, Junjie Wang, Lan Wang, Jingxian He, Keith M Kendrick, Bharat Biswal, Dezhong Yao, Zhen Liang, Weihua Zhao, Benjamin Becker   +17 more
wiley   +1 more source

Vaccine Dosing Considerations in Product Labels and ACIP Recommendations: A Review. [PDF]

Vaccines (Basel)
Saxena K, Mevis K, Toso S, Alyanak E, Hansen N, Potter A, Flannery M, Saraiya M.   +7 more
europepmc   +1 more source

Stacking Interventions Enhances Carbon Removals and Profitability of Livestock Production Systems

Advanced Science, EarlyView.
The study indicates that stacking multiple interventions aimed at maximising soil organic carbon (SOC) sequestration and enteric methane (CH4) reductions realizes greater abatement and profit do any singular intervention, especially when SOC sequestration accounts for a significant proportion of greenhouse gas emissions (GHG) mitigation. Abstract While
My Pham‐Kieu, Stephen Ives, Warwick Badgery, Matthew Tom Harrison   +3 more
wiley   +1 more source

Protection Against Persistent HPV-16/18 Infection After Different Number of Doses of Quadrivalent Vaccine in Girls and Young Women: A Randomized Clinical Trial.

JAMA Netw Open
Sauvageau C, Mayrand MH, Ouakki M, Ionescu IG, Coutlée F, Lacaille J, Benoit M, Gilca V.   +7 more
europepmc   +1 more source

A refined lion optimizer for deep learning. [PDF]

Sci Rep
Rong J, Ma C, Zhang Q, Cao Y, Kou W.
europepmc   +1 more source

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source

Pharmacokinetics of Pegaspargase with a Limited Sampling Strategy for Asparaginase Activity Monitoring in Children with Acute Lymphoblastic Leukemia. [PDF]

Pharmaceutics
Matteo C, Colombini A, Cancelliere M, Ceruti T, Fuso Nerini I, Porcu L, Zucchetti M, Silvestri D, Valsecchi MG, Parasole R, Vinti L, Bertorello N, Onofrillo D, Provenzi M, Chiocca E, Lo Nigro L, Bettini LR, Gotti G, Bungaro S, Schrappe M, Ubezio P, Rizzari C.   +21 more
europepmc   +1 more source

RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics

Advanced Science, EarlyView.
RAB5A‐mediated unjamming enhances active wetting through distinct biomechanical processes: a) upregulation of specific integrin subunits, enhanced focal adhesions kinetics and activity; b) supracellular organization relying on nanoscale integrin clustering, and the formation of a stiff and collective actin cable; and c) softening of the spheroid core ...
Grégoire Lemahieu, Paulina Moreno‐Layseca, Tobias Hub, Carlo Bevilacqua, Manuel Gómez‐González, Federica Pennarola, Federico Colombo, Andrew E. Massey, Leonardo Barzaghi, Andrea Palamidessi, Leon‐Luca Homagk, Samuel F. H. Barnett, Alexander X. Cartagena‐Rivera, Christine Selhuber‐Unkel, Robert Prevedel, Xavier Trepat, Joachim P. Spatz, Johanna Ivaska, Giorgio Scita, Elisabetta Ada Cavalcanti‐Adam   +19 more
wiley   +1 more source

Biweekly dosing of trifluridine-tipiracil reduces rates of myelosuppression while maintaining efficacy in patients with metastatic colorectal cancer. [PDF]

Oncologist
Cann C, LaPelusa M, Cimino S, Cancelliere V, Dow-Hillgartner E, Zhao Z, Deming D, Eng C.   +7 more
europepmc   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source