Advanced Science, EarlyView.Climate change reshapes the spatial alignment between crop production and environmental resources. Using multi‐source data and a crop model, integrated climatic, water, and soil endowments for maize and wheat are quantified and compared with harvest distributions.
Zheng'e Su +13 more
wiley +1 more source
The Novel Progressive Ratio with Reset Task Reveals Adaptive Effort-Delay Trade-Offs. [PDF]
eNeuroEdelstein GA.
europepmc +1 more source
Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model
Advanced Science, EarlyView.A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen +15 more
wiley +1 more source
Behavioral history effects on the maintenance of schedule-induced drinking in rats. [PDF]
J Exp Anal BehavLópez-Tolsa GE, Ardoy J, Pellón R.
europepmc +1 more source
PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe
Advanced Science, EarlyView.This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao +14 more
wiley +1 more source
A Bayesian pharmacokinetics integrated phase I-II design to optimize dose-schedule regimes. [PDF]
BiostatisticsLu M, Yuan Y, Liu S.
europepmc +1 more source
Advanced Science, EarlyView.This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen +8 more
wiley +1 more source
Feasibility of a 50% Dosing Interval Extension of Anti-IL-5 Biologics in Patients with Severe Asthma in Clinical Remission: A Real-World Validation Study. [PDF]
J Asthma AllergyVergles M +7 more
europepmc +1 more source
Advanced Science, EarlyView.An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang +8 more
wiley +1 more source
The Perceptions of Victorian Rural Community Pharmacists on the Dispensing and Supply of Vapes for Smoking Cessation and Nicotine Dependence: A Qualitative Study. [PDF]
Aust J Rural HealthBurtonClay-McMahon E +4 more
europepmc +1 more source