Randomized Phase 2 Trial of an Extended and Flexible Dosing Schedule of <sup>177</sup>Lu-PSMA Molecular Radiotherapy in Patients with Metastatic Castration-Resistant Prostate Cancer (FLEX-MRT): Study Protocol. [PDF]
Holzgreve A +18 more
europepmc +1 more source
DYNAMIC SCHEDULING OF HANDLING EQUIPMENT AT AUTOMATED CONTAINER TERMINALS
P.J.M. Meersmans, Albert Wagelmans
openalex +1 more source
A prior knowledge‐guided diffusion model augmented by physics‐constrained active learning is developed to design high‐asymmetry terahertz metamaterials. Trained on only a small set of classical structures, the model efficiently generates new high‐metrics designs.
Qiqi Dai +7 more
wiley +1 more source
Multicriteria scheduling of two-subassembly products with batch availability and precedence constraints. [PDF]
Wen Z, Li S.
europepmc +1 more source
Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang +25 more
wiley +1 more source
Acute or Chronic β-Caryophyllene Systemic Administration in Healthy Adult Male Mice Does Not Modulate Anxiety-Like Extinction Behavior Induced by Subsequent Re-Exposure to 3D Maze. [PDF]
Monteiro RFM +10 more
europepmc +1 more source
Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin +4 more
wiley +1 more source
An optimized novel lightweight block cipher for image encryption. [PDF]
Mohanapriya R, Nithish KV.
europepmc +1 more source
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour +14 more
wiley +1 more source

