Results 111 to 120 of about 1,289,331 (411)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

The sense of agency shapes body schema and peripersonal space

open access: yesScientific Reports, 2018
Body schema, a sensorimotor representation of the body used for planning and executing movements, is plastic because it extends by using a tool to reach far objects.
Mariano D’Angelo   +4 more
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Examining the Scope and Concept of Schema: Should We Look Beyond Cognitive Structures?

open access: yesPsychological Topics, 2010
Traditionally, cognitive therapy and the cognitive-behavior therapies have focused on three levels of cognitive phenomenon: automatic thoughts, cognitive distortion, and underlying assumptions. Underlying assumptions constitute the general notion of what
Frank M. Dattilio
doaj  

Semi Automatic Construction of ShEx and SHACL Schemas [PDF]

open access: yesarXiv, 2019
We present a method for the construction of SHACL or ShEx constraints for an existing RDF dataset. It has two components that are used conjointly: an algorithm for automatic schema construction, and an interactive workflow for editing the schema. The schema construction algorithm takes as input sets of sample nodes and constructs a shape constraint for
arxiv  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Cognitive Approach to Word Formation

open access: yesTaikomoji kalbotyra, 2013
Structural approach to word formation in Lithuanian is still dominant, meanwhile cognitive insights have not been applied yet. The object of this paper is the aspects of cognitive grammar to word formation.
Lina Inčiuraitė
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Semantics of Distinguishing Criteria: from Subjective to Intersubjective [PDF]

open access: yesInterdisciplinary Description of Complex Systems, 2012
In this article we are aiming to build cognitive semantics over a first person perspective. Our goal is to specify meanings connected to cognitive agents, rooted in their experience and separable from language, covering a wide spectrum of cognitions ...
Martin Takac, Jan Sefranek
doaj  

The Color and Content of Their Fears: A Short Analysis of Racial Profiling [PDF]

open access: yes, 2016
In response to Zack’s “White Privilege​ and Black Rights”, I consider her account of the hunting schema in light of police violence against black women.
Cherry, Myisha
core  

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