Results 81 to 90 of about 71,535 (286)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Optimization Design of Computer Network Reliability Based on Genetic Algorithms
Chemical Engineering Transactions, 2016 With the acceleration of the process of information society, not only the user's computer communication networks is increasing, but also the rapid expansion of computer communication network connecting regional scale and network connections.
L.J. Liu
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
phyloDB: A framework for large-scale phylogenetic analysis of sequence based typing data
SoftwareXPHYLODB is a modular and extensible framework for large-scale phylogenetic analyses of sequence based typing data, which are essential for understanding epidemics evolution. It relies on the Neo4j graph database for data storage and processing, providing
Bruno Lourenço +3 more
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CONSERVATION APPROACH TO THE INDUSTRIAL HERITAGE OF VOJVODINA
Facta Universitatis. Series: Architecture and Civil Engineering, 2019 This article presents new research, which has the objective of defining theoretical and methodological approaches to valorisation and conservation of the industrial heritage.
Anica Draganić
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Retracted: Research of Schema Evolution and Implementation Scheme Optimization in AI-Enabled Embedded Systems [PDF]
, 2023 Wireless Communications and Mobile Computing
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
An IDE-based, integrated solution to Schema Evolution of Object-Oriented Software [PDF]
, 2009 Marco Piccioni +3 more
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Hans Jonas: riflessioni etiche e speculazioni teologiche nel pensiero “dopo Auschwitz” [PDF]
S&F_scienzaefilosofia.it, 2020 Hans Jonas: Ethics and Theology in the thought “after Auschwitz” Hans Jonas radically transformed the question of theodicy into the question of the justification of man, rejecting the notion of God's power in history.
IAIA, GAETANO
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