Results 31 to 40 of about 656,169 (307)
On complexity of optimized crossover for binary representations [PDF]
, 2006 We consider the computational complexity of producing the best possible offspring in a crossover, given two solutions of the parents. The crossover operators are studied on the class of Boolean linear programming problems, where the Boolean vector of ...
Eremeev, Anton
core +3 more sources
Molecular Oncology, EarlyView.This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang +10 more
wiley +1 more source
A self-organizing random immigrants genetic algorithm for dynamic optimization problems [PDF]
, 2007 This is the post-print version of the article. The official published version can be obtained from the link below - Copyright @ 2007 SpringerIn this paper a genetic algorithm is proposed where the worst individual and individuals with indices close to ...
D.A. Goldberg +9 more
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Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
Portraits of genetic algorithms [PDF]
, 1993 The classical theoretical foundations of Genetic Algorithms are based on the schema theorem. This theorem is an inequality first discussed by Holland in 1975. In 1990, Vose developed the exact schema theorem, replacing the inequality by an equality. This
Juliany, Jenny
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Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Optimization Aspects of Carcinogenesis
, 2009 Any process in which competing solutions replicate with errors and numbers of their copies depend on their respective fitnesses is the evolutionary optimization process.
Brutovsky, B., Horvath, D.
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Variable grouping in multivariate time series via correlation [PDF]
, 2001 The decomposition of high-dimensional multivariate time series (MTS) into a number of low-dimensional MTS is a useful but challenging task because the number of possible dependencies between variables is likely to be huge.
Liu, X, Swift, S, Tucker, A
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Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim +8 more
wiley +1 more source