Results 51 to 60 of about 134,507 (290)
Database queries and constraints via lifting problems
, 2013 Previous work has demonstrated that categories are useful and expressive models for databases. In the present paper we build on that model, showing that certain queries and constraints correspond to lifting problems, as found in modern approaches to ...
Barr +15 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
An Approach for Supporting Ad-hoc Modifications in Distributed Workflow Management Systems [PDF]
, 2007 Supporting enterprise-wide or even cross-organizational business processes is a characteristic challenge for any workflow management system (WfMS). Scalability at the presence of high loads as well as the capability to dynamically modify running workflow
Bauer, T., Reichert, M.U.
core +2 more sources
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
3D UNDERGROUND LAND ADMINISTRATION BY STANDARDIZED GEOINFORMATION [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information SciencesThe density of the built environment is growing due to the migration from rural areas to urban areas. The challenges that should be addressed are therefore increased in today’s built environment.
D. Guler
doaj +1 more source
Database independent Migration of Objects into an Object-Relational Database [PDF]
, 2002 This paper reports on the CERN-based WISDOM project which is studying the serialisation and deserialisation of data to/from an object database (objectivity) and ORACLE 9i.Comment: 26 pages, 18 figures; CMS CERN Conference Report ...
Ali, Arshad +4 more
core +1 more source
Hanging In, Stepping up and Stepping Out: Livelihood Aspirations and Strategies of the Poor Development in Practice [PDF]
, 2009 In recent years understanding of poverty and of ways in which people escape from or fall into poverty has become more holistic. This should improve the capabilities of policy analysts and others working to reduce poverty, but it also makes analysis more ...
Anderson, S. +6 more
core +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source