Results 61 to 70 of about 134,507 (290)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Toward the Integrated Framework Analysis of Linkages among Agrobiodiversity, Livelihood Diversification, Ecological Systems, and Sustainability amid Global Change

Land, 2016
Scientific and policy interest in the biological diversity of agriculture (agrobiodiversity) is expanding amid global socioeconomic and environmental changes and sustainability interests. The majority of global agrobiodiversity is produced in smallholder
Karl S. Zimmerer, Steven J. Vanek
doaj   +1 more source

HepData and JetWeb: HEP data archiving and model validation [PDF]

, 2006
The CEDAR collaboration is extending and combining the JetWeb and HepData systems to provide a single service for tuning and validating models of high-energy physics processes.
Buckley, A., Butterworth, J. M., Monk, J., Nurse, E., Stirling, W. J., Waugh, B., Whalley, M. R.   +6 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Statistical Thermodynamics and Physical Kinetics of Structural Changes of Quasi-Binary Solid Solutions Based on the Close-Packed Simple Lattices (According to the Data About Evolution of a Pattern of Scattering of Waves of Various Kinds)

Успехи физики металлов, 2011
The review is concerned with studies of transformation of various types of atomic order during its relaxation from non-equilibrium state to equilibrium one and determination of microscopic parameters of migration of atoms, which characterize such ...
V. A. Tatarenko, O. V. Sobol’, D. S. Leonov, Yu. A. Kunyts’kyy, S. M. Bokoch
doaj   +1 more source

The new epigraphic monument of Otilovići near Pljevlja [PDF]

Starinar, 2012
The remains of an early Christian church were discovered, by chance, during the leveling of the terrain in Otilovići near Pljevlja where there were two monuments, or pyramidal cipi.
Cvijetić Jelena Lj.
doaj   +1 more source

XML-based genetic rules for scene boundary detection in a parallel processing environment [PDF]

, 2007
Genetic programming is based on Darwinian evolutionary theory that suggests that the best solution for a problem can be evolved by methods of natural selection of the fittest organisms in a population.
Angelides, MC, Parmar, MJ
core  

Converting relational databases into object relational databases [PDF]

, 2010
This paper proposes an approach for migrating existing Relational DataBases (RDBs) into Object-Relational DataBases (ORDBs). The approach is superior to existing proposals as it can generate not only the target schema but also the data instances.
Ali, Akhtar, Maatuk, Abdelsalam, Rossiter, Nick   +2 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The Narrative of Parthenius (Ageev) on the Accession of the Kyrgyz Steppe to Russia: from the History of Christianization of Central Asian Peoples [PDF]

Гуманитарный вектор
In the context of studying the history of the Orthodox presence of Russia in Central Asia and Western China, we have analyzed the well-known narrative source – the note of schema-abbot Parthenius (Aggeyev 1806–1878) “First news of the Russians in Ghulja”
Irina Yu. Smirnova
doaj   +1 more source