Results 71 to 80 of about 134,507 (290)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Integrating longitudinal mental health data into a staging database: harnessing DDI-lifecycle and OMOP vocabularies within the INSPIRE Network Datahub

Frontiers in Big Data
BackgroundLongitudinal studies are essential for understanding the progression of mental health disorders over time, but combining data collected through different methods to assess conditions like depression, anxiety, and psychosis presents significant ...
Bylhah Mugotitsa, Bylhah Mugotitsa, Tathagata Bhattacharjee, Michael Ochola, Dorothy Mailosi, David Amadi, Pauline Andeso, Joseph Kuria, Reinpeter Momanyi, Evans Omondi, Evans Omondi, Dan Kajungu, Jim Todd, Agnes Kiragga, Agnes Kiragga, Jay Greenfield   +15 more
doaj   +1 more source

Evaluation des bassins par modélisation intégrée en deux dimensions des transferts techniques, de l'écoulement des fluides, de la genèse et de la migration des hydrocarbures Basin Evaluation by Integrated Two-Dimensional Modeling of Heat Transfer, Fluid Flow, Hydrocarbon Generation, and Migration

Oil & Gas Science and Technology, 2006
Le modèle de bassin exposé dans cet article décrit les phénomènes physiques et chimiques qui contrôlent la formation d'accumulations commerciales, dans le cadre évolutif d'un bassin sédimentaire affecté par la subsidence : transfert de chaleur ...
Chenet P. Y., Bessis F., Ungerer P., Burrus J., Doligez B.   +4 more
doaj   +1 more source

Predicting Anchor Links between Heterogeneous Social Networks

, 2016
People usually get involved in multiple social networks to enjoy new services or to fulfill their needs. Many new social networks try to attract users of other existing networks to increase the number of their users. Once a user (called source user) of a
Khodadadi, Ali, Rabiee, Hamid R., Sajadmanesh, Sina   +2 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A Framework for Quality-Driven Delivery in Distributed Multimedia Systems [PDF]

, 2006
In this paper, we propose a framework for Quality-Driven Delivery (QDD) in distributed multimedia environments. Quality-driven delivery refers to the capacity of a system to deliver documents, or more generally objects, while considering the users ...
Gerbé, Olivier, Jaumard, Brigitte, Kerhervé, Brigitte, Nguyen, Kim-Khoa   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Importance des phénomènes de migration verticale des hydrocarbures Significance of Vertical Migration Phenomea of Hydrocarbons

Oil & Gas Science and Technology, 2006
Cette publication a pour but de démonter les mécanismes de migration verticale des hydrocarbures et d'en analyser les conséquences, à partir d'exemples concrets choisis sur les domaines d'activité de la Société Nationale Elf Aquitaine (Production) [SNEA (
Chiarelle A., Du Rouchet J.
doaj   +1 more source

Data Dictionary Services in XNAT and the Human Connectome Project

Frontiers in Neuroinformatics, 2014
The XNAT informatics platform is an open source data management tool used by biomedical imaging researchers around the world. An important feature of XNAT is its highly extensible architecture: users of XNAT can add new data types to the system to ...
Rick eHerrick, Michael eMcKay, Timothy eOlsen, Will eHorton, Mark eFlorida, Charlie eMoore, Daniel S Marcus   +6 more
doaj   +1 more source