Results 41 to 50 of about 100,413 (242)

Understanding the phenomenological experiences of schema therapy for those with an eating disorder

Qualitative Research in Medicine & Healthcare
Schema therapy expands traditional cognitive-behavioral models, weakening early maladaptive schemas and schema modes while strengthening adaptive modes.
Alice Cunningham, Marie Reid, Stephanie Sayan, Richard Hammersley   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

TREATING NARCISSISTIC PERSONALITY DISORDER WITH SCHEMA THERAPY – A CASE STUDY

Anthropological Researches and Studies
Objectives. This case study endeavors to provide an in-depth understanding of the schema and mode structure of narcissistic personality disorder (NPD) and to illustrate a possible therapeutic approach using schema therapy (ST). Material and methods.
Maria Cristina STERIE
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A mixed methods study of schema modes amongst people living with eating disorders

Journal of Eating Disorders
Background Schema therapy is promising for people with eating disorders, especially those unresponsive to cognitive behavioural therapy. Complex underlying psychological constructs include dysfunctional schemas and maladaptive modes.
Clare Marney, Marie Reid, Bernice Wright
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Comparison of the effectiveness of family-centered schema therapy, with and without supportive therapy in reducing the symptoms of patients with borderline personality disorder

Chronic Diseases Journal, 2022
BACKGROUND: Based on the increasing spread of chronic diseases and their destructive role, a borderline personality disorder is the most common personality disorder in the group of chronic mental diseases.
Kianoosh Azizi, Mokhtar Arefi, Omid Moradi   +2 more
doaj   +1 more source

Early maladaptive schemas and schema modes of men and women in different stages of adulthood [PDF]

Vestnik of Saint Petersburg University. Psychology, 2016
Исследование выполнено при финансовой поддержке РГНФ в рамках исследовательского проекта № 15-06-10825 («Ранние дезадаптивные схемы и субъективные переживания детства в связи с совладающим поведением взрослых»).
Maria V. Galimzyanova, Pavel M. Kasyanik, Elena V. Romanova   +2 more
openaire   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source