Results 21 to 30 of about 20,757 (184)

Can antibody conjugated nanomicelles alter the prospect of antibody targeted therapy against schistosomiasis mansoni?

PLoS Neglected Tropical Diseases, 2023
BackgroundCLA (conjugated linoleic acid)-mediated activation of the schistosome tegument-associated sphingomyelinase and consequent disruption of the outer membrane might allow host antibodies to access the apical membrane antigens. Here, we investigated
Eglal I Amer, Sonia R Allam, Aceel Y Hassan, Esmail M El-Fakharany, Mona M Agwa, Sherine N Khattab, Eman Sheta, Marwa H El-Faham   +7 more
doaj   +1 more source

A PAL for Schistosoma mansoni PHM [PDF]

Molecular and Biochemical Parasitology, 2010
Parasitic helminth neuromuscular function is a proven target for chemotherapeutic control. Although neuropeptide signalling plays a key role in helminth motor function, it has not yet provided targets for known anthelmintics. The majority of biologically active neuropeptides display a C-terminal amide (NH(2)) motif, generated exclusively by the ...
Atkinson, Louise, McVeigh, Paul, Kimber, Michael, Marks, Nicola, Eipper, Betty, Mains, Richard, Day, Timothy, Maule, Aaron   +7 more
openaire   +3 more sources

Prevalence of malaria and Schistosoma mansoni coinfection in sub Saharan Africa: A systematic review and meta-analysis

Parasite Epidemiology and Control
Background: Malaria and schistosomiasis are two parasite illnesses that share transmission sites in distinct tropical climates. Malaria-schistosomiasis coinfection is widespread in Africa.
Wagaw Abebe, Birhanu Kassanew, Tadesse Misganaw, Agenagnew Ashagre, Getinet Kumie, Marye Nigatie, Yalewayker Gashaw, Ephrem Tamrat, Dagmawi Woldesenbet, Alembante Bazezew   +9 more
doaj   +1 more source

Contribuição ao levantamento da carta planorbídica do Estado de São Paulo: Pesquisa de focos com formas evolutivas do Schistosoma mansoni. II. Município de Peruibe (Litoral Sul do Estado de São Paulo) Contribution to the survey of the planorbid chart of the State of São Paulo (Brazil): Investigation of foci with evolutive forms of Schistosoma mansoni. II. Peruibe county (Southern coast of the State of São Paulo)

Revista de Saúde Pública, 1969
Em levantamento realizado em Peruibe, em janeiro de 1966, foram identificados focos de Biomphalaria tenagophila infestados com formas evolutivas do Schistosoma mansoni.In this work the occurence of Biomphalaria tenagophila naturally parasited by ...
Mário Demar Perez, Paulo de Toledo Artigas   +1 more
doaj   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Criadouros de Biomphalaria, temporários e permanentes, em Jaboatão dos Guararapes, PE Temporary and permanent breeding sites for Biomphalaria in Jaboatão dos Guararapes, PE

Revista da Sociedade Brasileira de Medicina Tropical, 2008
Realizou-se um inquérito malacológico em criadouros, permanentes e temporários, no bairro de Piedade, Jaboatão dos Guararapes, Pernambuco, entre novembro de 2006 e novembro de 2007 com o objetivo de conhecer a fauna malacológica dessa localidade, bem ...
Marco Antônio Andrade de Souza, Verônica Santos Barbosa, Tereza Neuma Guedes Wanderlei, Constança Simões Barbosa   +3 more
doaj   +1 more source

Phytochemistry, Chemotypic Diversity and Antimicrobial Potential of Essential Oils From Native Aromatic Plants of the Americas: A Systematic Review

Flavour and Fragrance Journal, EarlyView.
This review bridges ancestral indigenous knowledge with modern pharmacology, summarizing the phytochemistry and antimicrobial properties of essential oils from seven native American species. It highlights their significant activity against bacterial, fungal and parasitic pathogens, emphasizing their potential as sustainable therapeutic and agricultural
Arley Rey Páez, Mozaniel Santana de Oliveira, João Paulo Viana Leite   +2 more
wiley   +1 more source

Effects of Video‐Based Health Education on Birth Outcomes and Anaemia Status of Mothers in Dirashe District South Ethiopia: A Cluster Randomized Controlled Trial

Maternal &Child Nutrition, EarlyView.
ABSTRACT Undernutrition and infections during pregnancy result in low birth weight (LBW) and maternal anaemia. Social behaviour change communication (SBCC) can promote recommended health practices, potentially improving maternal and neonatal outcomes.
Wanzahun Godana Boynito, Kidus Temesgen Worsa, Befikadu Tariku Gutema, Yordanos Gizachew Yeshitila, Godana Yaya Tessema, Tsegaye Yohanis, Stefaan De Henauw, Piet Cools, Bruno Levecke, Souheila Abbeddou   +9 more
wiley   +1 more source