Results 121 to 130 of about 1,004,261 (415)

Genetic identification of brain cell types underlying schizophrenia

Nature Genetics, 2017
With few exceptions, the marked advances in knowledge about the genetic basis of schizophrenia have not converged on findings that can be confidently used for precise experimental modeling. By applying knowledge of the cellular taxonomy of the brain from
N. Skene, J. Bryois, Trygve E Bakken, G. Breen, J. Crowley, Héléna A. Gaspar, P. Giusti-Rodríguez, R. Hodge, Jeremy A. Miller, A. B. Muñoz-Manchado, M. O’Donovan, M. Owen, A. Pardiñas, J. Ryge, J. Walters, S. Linnarsson, E. Lein, P. Sullivan, J. Hjerling-Leffler   +18 more
semanticscholar   +1 more source

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD): Executive summary of recommendations for primary care

Alzheimer's &Dementia, EarlyView.
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri, Bradford C. Dickerson, Carolyn Clevenger, Jason Karlawish, David Knopman, Pei‐Jung Lin, Mary Norman, Chiadi Onyike, Mary Sano, Susan Scanland, Maria Carrillo   +10 more
wiley   +1 more source

Abnormal negative feedback processing in first episode schizophrenia: evidence from an oculomotor rule switching task [PDF]

, 2011
Background. Previous studies have shown that patients with schizophrenia are impaired on executive tasks, where positive and negative feedbacks are used to update task rules or switch attention.
Andreasen, Andreasen, E. M. Joyce, M. A. Ron, T. L. Hodgson, T. R. E. Barnes, V. C. Huddy, Wechsler, Wechsler   +8 more
core   +1 more source

Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies.

Archives of General Psychiatry, 2003
CONTEXT There are many published twin studies of schizophrenia. Although these studies have been reviewed previously, to our knowledge, no review has provided quantitative summary estimates of the impact of genes and environment on liability to ...
P. Sullivan, K. Kendler, M. Neale
semanticscholar   +1 more source

Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances

Animal Models and Experimental Medicine, EarlyView.
In this study, we classified postoperative patients into poor sleepers (PS) and good sleepers (GS) based on the bispectral index (BIS), and transplanted their fecal microbiota to pseudo‐germ‐free rats to analyze the sleep changes in rats and the potential mechanism.
Hui Zhong, Meiru Jiang, Kun Yuan, Fang Sheng, Xiuyun Xu, Yong Cui, Xijia Sun, Wenfei Tan   +7 more
wiley   +1 more source

Reward Processing as an Indicator of Vulnerability or Compensatory Resilience in Psychoses? Results From a Twin Study

Biological Psychiatry Global Open Science, 2023
Background: Findings of reward disturbances in unaffected relatives of patients with schizophrenia suggest reward disturbances as an endophenotype for schizophrenia.
Mette Ødegaard Nielsen, Egill Rostrup, Rikke Hilker, Christian Legind, Simon Anhøj, Trevor William Robbins, Barbara J. Sahakian, Birgitte Fagerlund, Birte Glenthøj   +8 more
doaj  

Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

Molecular Psychiatry, 2017
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies.
S. Kelly, N. Jahanshad, A. Zalesky, P. Kochunov, I. Agartz, C. Alloza, O. Andreassen, C. Arango, N. Banaj, S. Bouix, C. Bousman, R. Brouwer, J. Bruggemann, J. Bustillo, W. Cahn, V. Calhoun, D. Cannon, V. Carr, S. Catts, J. Chen, J.X. Chen, X. Chen, C. Chiapponi, K. K. Cho, V. Ciullo, A. Corvin, B. Crespo-Facorro, V. Cropley, P. de Rossi, C. Díaz-Caneja, E. Dickie, S. Ehrlich, F. Fan, Joshua Faskowitz, H. Fatouros-Bergman, L. Flyckt, J. Ford, J. Fouche, M. Fukunaga, M. Gill, D. Glahn, R. Gollub, E. Goudzwaard, H. Guo, R. Gur, R. Gur, T. Gurholt, R. Hashimoto, S. Hatton, F. Henskens, D. Hibar, I. Hickie, L. Hong, J. Horáček, F. Howells, H. H. Hulshoff Pol, C. Hyde, D. Isaev, A. Jablensky, P. Jansen, J. Janssen, E. Jönsson, L. Jung, R. Kahn, Z. Kikinis, K. Liu, P. Klauser, C. Knöchel, M. Kubicki, J. Lagopoulos, C. Langen, S. Lawrie, R. Lenroot, K. Lim, C. López-Jaramillo, A. Lyall, V. Magnotta, R. Mandl, D. Mathalon, R. McCarley, S. McCarthy-Jones, C. Mcdonald, S. McEwen, A. McIntosh, T. Melicher, R. Mesholam-Gately, P. Michie, B. Mowry, B. Mueller, D. Newell, P. O’Donnell, V. Oertel-Knöchel, L. Oestreich, S. Paciga, C. Pantelis, O. Pasternak, G. Pearlson, G. Pellicanò, A. Pereira, J. P. Pineda Zapata, F. Piras, S. Potkin, Adrian Preda, P. Rasser, D. Roalf, R. Roiz, A. Roos, D. Rotenberg, T. Satterthwaite, P. Savadjiev, U. Schall, R. Scott, M. Seal, L. Seidman, C. Shannon Weickert, C. Whelan, M. Shenton, J. Kwon, G. Spalletta, F. Španiel, E. Sprooten, M. Stäblein, Dan J Stein, S. Sundram, Y. Tan, S. Tan, S. Tang, H. Temmingh, L. Westlye, S. Tønnesen, D. Tordesillas-Gutiérrez, N. T. Doan, J. Vaidya, N. V. van Haren, C. Vargas, D. Vecchio, D. Velakoulis, A. Voineskos, J. Voyvodic, Z. Wang, P. Wan, D. Wei, T. Weickert, H. Whalley, T. White, T. Whitford, J. Wojcik, H. Xiang, Z. Xie, H. Yamamori, F. Yang, N. Yao, G. Zhang, J. Zhao, T. V. van Erp, J. Turner, P. Thompson, G. Donohoe   +157 more
semanticscholar   +1 more source

Psychoses of Epilepsy: Unravelling the Phenotypic and Genotypic Features

Annals of Neurology, EarlyView.
Objectives We analyzed the genotypic and phenotypic features of patients with psychosis of epilepsy (POE). Methods Patients with POE recruited to an epilepsy genetics research program underwent phenotyping and genetic analysis. The latter included screening for rare pathogenic variants in epilepsy genes, and polygenic risk score (PRS) calculation for ...
Genevieve Rayner, Eliza Honybun, Melanie Bahlo, Karen L. Oliver, Ingrid E. Scheffer   +4 more
wiley   +1 more source

Quality of life in Romanian patients with schizophrenia based on gender, type of schizophrenia, therapeutic approach, and family history [PDF]

, 2018
The low quality of life of patients with schizophrenia has been extensively discussed and investigated. Various aspects from gender, socio-demographic profile, and/or type of neuroleptic treatment have been taken into account in describing this condition.
Alexinschi, Ovidiu Eugen, Brîncuș, Călin, Giurgiuca, Ana, Matei, Valentin Petre, Rosca, Elena Alina   +4 more
core   +3 more sources

Current Concepts and Treatments of Schizophrenia

Molecules, 2018
Schizophrenia is a debilitating mental illness which involves three groups of symptoms, i.e., positive, negative and cognitive, and has major public health implications. According to various sources, it affects up to 1% of the population.
Piotr Stępnicki, Magda Kondej, A. Kaczor   +2 more
semanticscholar   +1 more source