Results 71 to 80 of about 538 (159)
Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley +1 more source
Lifespan Trajectories of Asymmetry in White Matter Tracts
(A) Large‐scale lifespan modeling of white matter asymmetry. Diffusion MRI data from 35,000+ individuals (0‐100 years) across 50 cohorts were used to generate normative lifespan trajectories of white matter asymmetry. Thirty bilateral tracts were segmented, and microstructural (FA, MD, AD, RD) and macrostructural (volume, length) features were ...
Sam Bogdanov +72 more
wiley +1 more source
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Can the brain register the emotional valence of brief exposures of complex natural stimuli under conditions of forward and backward masking, and under ...
Shaw, Lynda Joan
core
Experience Therapy: How Service Experiences Regulate Everyday Negative Affect
ABSTRACT In today's fast‐paced and high‐pressure society, maintaining emotional well‐being requires effective strategies for managing everyday negative affect. This research examines the role of service experiences in reducing negative affect and introduces experience therapy as a novel strategy for affect regulation.
Chang Ma +3 more
wiley +1 more source
Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele +7 more
wiley +1 more source
ABSTRACT Machine learning approaches have been increasingly applied to social media text data for mental health risk detection. However, existing studies vary widely in target outcomes, data sources, labeling strategies, and evaluation practices, and a structured overview of recent research remains limited.
Yiqing He, Yinning He, Darong Liu
wiley +1 more source
The New Zealand Wars Documentary Series: Discursive Struggle and Cultural Memory.
The 1998 television broadcast of The New Zealand Wars documentary series was a significant public event, which had a major impact on a broad range of communities and individuals in Aotearoa New Zealand. This popular television history engaged with issues
Perrott, Lisa
core
The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi‐Omics Integration
Multi‐omics aging clocks capture biological heterogeneity beyond single‐omics models, improving risk stratification. Key challenges include unknown biological meaning, timescale mismatches, and validation gaps. Future clocks must distinguish pathological damage from adaptive remodeling—damage accumulation is the most actionable target for anti‐aging ...
Liying Liu +13 more
wiley +1 more source
Action control in uncertain environments
A long-standing dichotomy in neuroscience pits automatic or reflexive drivers of behaviour against deliberate or reflective processes. In this thesis I explore how this concept applies to two stages of action control: decision-making and response ...
Smittenaar, P
core
Abstract Objectives Autistic individuals are at increased risk of psychotic experiences and being diagnosed with psychotic disorders. This association may result from methodological issues, including the misinterpretation of psychosis questionnaires by autistic individuals and clinicians' difficulty distinguishing between the conditions.
Michael R. Miles +2 more
wiley +1 more source

