Reactive oxygen species rescue regeneration after silencing the MAPK–ERK signaling pathway in Schmidtea mediterranea [PDF]
Scientific Reports, 2021 Despite extensive research on molecular pathways controlling the process of regeneration in model organisms, little is known about the actual initiation signals necessary to induce regeneration. Recently, the activation of ERK signaling has been shown to
V. Jaenen +7 more
doaj +5 more sources
Analysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death [PDF]
Scientific Reports, 2021 The forkhead box (Fox) genes encode transcription factors that control several key aspects of development. Present in the ancestor of all eukaryotes, Fox genes underwent several duplications followed by loss and diversification events that gave rise to ...
Eudald Pascual-Carreras +6 more
doaj +4 more sources
Variation in phenotype, genotype, and somatic diversity among asexual Schmidtea mediterranea planarians [PDF]
iScienceSummary: Most multicellular life reproduces sexually, utilizing a single-celled stage that acts as a genetic bottleneck. This bottleneck limits the evolution of selfish cell adaptations by ensuring all cells descend from a single progenitor.
Simon Kershenbaum +6 more
doaj +4 more sources
Neoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea [PDF]
Stem Cell Reports, 2014 Planarians can regenerate any missing body part in a process requiring dividing cells called neoblasts. Historically, neoblasts have largely been considered a homogeneous stem cell population.
M. Lucila Scimone +3 more
doaj +7 more sources
TRAF-like Proteins Regulate Cellular Survival in the Planarian Schmidtea mediterranea [PDF]
iScience, 2020 Summary: Tissue homeostasis relies on the timely renewal of cells that have been damaged or have surpassed their biological age. Nonetheless, the underlying molecular mechanism coordinating tissue renewal is unknown.
Benjamin Ziman +3 more
doaj +4 more sources
Mitogen-like Cerium-Based Nanoparticles Protect Schmidtea mediterranea against Severe Doses of X-rays. [PDF]
Int J Mol Sci, 2023 Novel radioprotectors are strongly demanded due to their numerous applications in radiobiology and biomedicine, e.g., for facilitating the remedy after cancer radiotherapy.
Filippova KO +8 more
europepmc +4 more sources
Impact of host physiology and external stressors on the bacterial community of Schmidtea mediterranea [PDF]
Scientific ReportsTo fully comprehend host-microorganism interactions, it is crucial to understand the composition and diversity of the microbiome, as well as the factors that shape these characteristics. We investigated microbiome variation using the freshwater planarian
Karolien Bijnens +8 more
doaj +3 more sources
Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea [PDF]
Nature Cell Biology, 2021 Regeneration requires the coordination of stem cells, their progeny and distant differentiated tissues. Here, we present a comprehensive atlas of whole-body regeneration in Schmidtea mediterranea and identify wound-induced cell states. An analysis of 299,
Blair W Benham-Pyle +2 more
exaly +3 more sources
Maintenance of Schmidtea mediterranea in the Laboratory [PDF]
Bio-Protocol, 2018 In the last years, planarians have emerged as a unique model animal for studying regeneration and stem cells biology. Although their remarkable regenerative abilities are known for a long time, only recently the molecular tools to understand the biology ...
Nídia Sousa, Teresa Adell
doaj +4 more sources
Chryseobacterium schmidteae sp. nov. a novel bacterial species isolated from planarian Schmidtea mediterranea [PDF]
Scientific Reports, 2021 Marseille-P9602T is a Chryseobacterium-like strain that we isolated from planarian Schmidtea mediterranea and characterized by taxono-genomic approach.
Luis Johnson Kangale +3 more
doaj +3 more sources