Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice
Aging Cell, Volume 24, Issue 11, November 2025.Resident stem cells from aged planaria and murine skeletal muscle possess some inherent abilities to mitigate signs of aging after tissue regeneration. ABSTRACT Adult resident stem cells are capable of regenerating tissues that manifest signs of “rejuvenation” in flatworms and mice of older ages.
Kevin A. Murach +8 more
wiley +1 more source
Hedgehog signaling regulates gene expression in planarian glia
eLife, 2016 Hedgehog signaling is critical for vertebrate central nervous system (CNS) development, but its role in CNS biology in other organisms is poorly characterized. In the planarian Schmidtea mediterranea, hedgehog (hh) is expressed in medial cephalic ganglia
Irving E Wang +4 more
doaj +1 more source
The pioneer factor Smed-gata456-1 is required for gut cell differentiation and maintenance in planarians [PDF]
, 2018 How adult stem cells differentiate into different cell types remains one of the most intriguing questions in regenerative medicine. Pioneer factors are transcription factors that can bind to and open chromatin, and are among the first elements involved ...
Adell i Creixell, Teresa +3 more
core +1 more source
Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection
BioEssays, Volume 47, Issue 9, September 2025.Embryonic radial glia (RG) generate neurons, glial cells, and later adult neural stem cells, which sustain adult neurogenesis (top, left to right). Human‐specific genetic modifications (blue arrow), selected to boost early RG neurogenic activity, may lead to premature RG exhaustion and reduced adult neurogenesis in the human brain (bottom).
David Morizet, Laure Bally‐Cuif
wiley +1 more source
An adaptable chromosome preparation methodology for use in invertebrate research organisms
BMC Biology, 2018 Background The ability to efficiently visualize and manipulate chromosomes is fundamental to understanding the genome architecture of organisms. Conventional chromosome preparation protocols developed for mammalian cells and those relying on species ...
Longhua Guo +7 more
doaj +1 more source
Schmidtea mediterranea phylogeography: an old species surviving on a few Mediterranean islands? [PDF]
, 2011 Background: Schmidtea mediterranea (Platyhelminthes, Tricladida, Continenticola) is found in scattered localities on a few islands and in coastal areas of the western Mediterranean. Although S.
Baguñà, Jaume +5 more
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Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ.
, 2015 Cystic kidney diseases (CKDs) affect millions of people worldwide. The defining pathological features are fluid-filled cysts developing from nephric tubules due to defective flow sensing, cell proliferation and differentiation.
Alexander, R. +6 more
core +1 more source
DNA damage and tissue repair: What we can learn from planaria. [PDF]
, 2019 Faithful renewal of aging and damaged tissues is central to organismal lifespan. Stem cells (SCs) generate the cellular progeny that replenish adult tissues across the body but this task becomes increasingly compromised over time. The age related decline
Barghouth, Paul G +3 more
core +1 more source
Reviews in Aquaculture, Volume 17, Issue 4, September 2025.Single‐cell sequencing sheds light on cellular diversity, development, and immune evolution in fish and invertebrates, offering new insights into environmental adaptation and evolutionary biology. ABSTRACT Single‐cell sequencing (SCS) technology has revolutionized the study of cellular heterogeneity by enabling the exploration of biological processes ...
Chongbin Hu +5 more
wiley +1 more source
Distribuzione geografica in Sardegna di planarie d'acqua dolce appartenenti alle specie Dugesia (S.) polychroa e Dugesia (S.) mediterranea (Turbellaria, Tricladida) [PDF]
, 1982 Geographical distribution in Sardinia of different karyological biotypes of Dugesia (Schmidtea)polychroa and Dugesia (S.) mediterranea has been investigated. On the whole, 4 biotypes of Dugesia (S.)Polychroa (A, C.
Casu, Salvatore +2 more
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