Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo
Cell Reports, 2015 Histone H3 lysine 4 trimethylation (H3K4me3) is known to correlate with both active and poised genomic loci, yet many questions remain regarding its functional roles in vivo. We identify functional genomic targets of two H3K4 methyltransferases, Set1 and
Elizabeth M. Duncan +3 more
doaj +1 more source
Cellular and Molecular Responses Unique to Major Injury Are Dispensable for Planarian Regeneration [PDF]
, 2019 The fundamental requirements for regeneration are poorly understood. Planarians can robustly regenerate all tissues after injury, involving stem cells, positional information, and a set of cellular and molecular responses collectively called the “missing
Oderberg, Isaac Max +3 more
core +1 more source
bioRxivPost-transcriptional regulation has emerged as a key mechanism to regulate stem cell renewal and differentiation, which is essential for understanding tissue regeneration and homeostasis. Poly(A)-binding proteins are a family of RNA-binding proteins that
Namita Mukundan +5 more
semanticscholar +1 more source
Planarian (Platyhelminthes, Tricladida) Diversity and Molecular Markers: A New View of an Old Group [PDF]
, 2014 Planarians are a group of free-living platyhelminths (triclads) best-known largely due to long-standing regeneration and pattern formation research. However, the group"s diversity and evolutionary history has been mostly overlooked.
Riutort León, Marta +1 more
core +3 more sources
MAKER2: an annotation pipeline and genome-database management tool for second-generation genome projects [PDF]
, 2011 Background Second-generation sequencing technologies are precipitating major shifts with regards to what kinds of genomes are being sequenced and how they are annotated.
Carson Holt, Mark Yandell
core +1 more source
Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians
eLife, 2019 Kleiber’s law, or the 3/4 -power law scaling of the metabolic rate with body mass, is considered one of the few quantitative laws in biology, yet its physiological basis remains unknown.
Albert Thommen +10 more
doaj +1 more source
Descrizione di una nuova razza morfologica di Dugesia (Schmidtea) polychroa (Turbellaria, Tricladida) della Sardegna [PDF]
, 1983 A planarian of the Dugesia lugubris-polychroa group, characterized by triangular head, is reported from Sardinia. The apical position of the eyes is similar to the one found in Dugesia (Schmidtea) polychroa.
Casu, Salvatore +2 more
core
Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano. [PDF]
, 2015 The free-living flatworm, Macrostomum lignano has an impressive regenerative capacity. Following injury, it can regenerate almost an entirely new organism because of the presence of an abundant somatic stem cell population, the neoblasts.
Battistoni, Giorgia +14 more
core +2 more sources
Single-Cell Analysis Reveals Functionally Distinct Classes within the Planarian Stem Cell Compartment [PDF]
Planarians are flatworms capable of regenerating any missing body region. This capacity is mediated by neoblasts, a proliferative cell population that contains pluripotent stem cells.
Reddien, Peter +2 more
core +1 more source
Protein & Cell, 2018 Regeneration, relying mainly on resident adult stem cells, is widespread. However, the mechanism by which stem cells initiate proliferation during this process in vivo is unclear.
Xiao-Shuai Han +6 more
doaj +1 more source