Results 61 to 70 of about 16,935 (240)
Genes to Cells, Volume 28, Issue 11, Page 800-810, November 2023., 2023 We developed a method to isolate planarian viable cells for single‐cell transcriptome analysis. The sorted cells by our method demonstrated high cell viability and high quality in single‐cell RNA‐seq library construction. Abstract Preparing viable single cells is critical for conducting single‐cell RNA sequencing (scRNA‐seq) because the presence of ...
Yoshihito Kuroki, Kiyokazu Agata
wiley +1 more source
Neuronal sources of hedgehog modulate neurogenesis in the adult planarian brain
eLife, 2016 The asexual freshwater planarian is a constitutive adult, whose central nervous system (CNS) is in a state of constant homeostatic neurogenesis. However, very little is known about the extrinsic signals that act on planarian stem cells to modulate rates ...
Ko W Currie +2 more
doaj +1 more source
Gene nomenclature guidelines for the planarian Schmidtea mediterranea [PDF]
Developmental Dynamics, 2008 AbstractThe planarian Schmidtea mediterranea is rapidly emerging as an important model system for the study of stem cells, regeneration and tissue homeostasis. Left, the central nervous system as visualized by whole‐mount in situ hybridization with a probe against Smed‐synapsin (syn), the planarian homolog to the neurotransmitter release regulator. Top
Peter W, Reddien +2 more
openaire +2 more sources
m6A promotes planarian regeneration
Cell Proliferation, Volume 56, Issue 5, May 2023., 2023 As depicted in our model, during planarian homeostasis, the expression level of grn is held at a moderate level to inhibit overgrowth, as equivalent to grn expression level before amputation at 0 hpa. Upon injury, m6A modification selectively targets several important gene transcripts, including grn for degradation, manifested as its reduced expression
Guanshen Cui +16 more
wiley +1 more source
Small RNA pathways in Schmidtea mediterranea
The International Journal of Developmental Biology, 2012 Planarians are bilaterally symmetrical fresh water organisms capable of regenerating body parts from small fragments following bodily injury. Planarians possess a specialized population of pluripotent cells called neoblasts, which are responsible for their unique regenerative ability.
Alissa M, Resch, Dasaradhi, Palakodeti
openaire +3 more sources
Wound Repair and Regeneration, Volume 30, Issue 6, Page 636-651, November/December 2022., 2022 Abstract Xenopus laevis tadpoles can regenerate functional tails, containing the spinal cord, notochord, muscle, fin, blood vessels and nerves, except for a brief refractory period at around 1 week of age. At this stage, amputation of the tadpole's tail may either result in scarless wound healing or the activation of a regeneration programme, which ...
Phoebe A. Chapman +6 more
wiley +1 more source
Egr-5 is a post-mitotic regulator of planarian epidermal differentiation
eLife, 2015 Neoblasts are an abundant, heterogeneous population of adult stem cells (ASCs) that facilitate the maintenance of planarian tissues and organs, providing a powerful system to study ASC self-renewal and differentiation dynamics.
Kimberly C Tu +6 more
doaj +1 more source
SUMOylation controls stem cell proliferation and regional cell death through Hedgehog signaling in planarians. [PDF]
, 2017 Mechanisms underlying anteroposterior body axis differences during adult tissue maintenance and regeneration are poorly understood. Here, we identify that post-translational modifications through the SUMO (Small Ubiquitin-like Modifier) machinery are ...
Barghouth, Paul G +4 more
core +1 more source
phylogeography: an old species surviving on a few Mediterranean islands? [PDF]
, 2011 Schmidtea mediterranea (Platyhelminthes, Tricladida, Continenticola) is found in scattered localities on a few islands and in coastal areas of the western Mediterranean. Although S. mediterranea is the object of many regeneration studies, little is known
Lázaro Iglesias, Eva Ma. +5 more
core +2 more sources
G3: Genes, Genomes, Genetics, 2016 Exploiting the conservation of various features of mitochondrial genomes has been instrumental in resolving phylogenetic relationships. Despite extensive sequence evidence, it has not previously been possible to conclusively resolve some key aspects of ...
Eric Ross +3 more
doaj +1 more source