Results 71 to 80 of about 581,895 (318)
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
, 2023 When passing on the position of president of the Brazilian Academy of Sciences to Menezes de Oliveira in 1937, Alvaro Alberto da Mota e Silva praised his successor in the following way: Not only as a man of science does Menezes de Oliveira ascend in admiration from his peers. The refined moral elegance, the aesthetic sense and the finesse of ‘gentleman’
openaire +2 more sources
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Persona-Knowledge Dialogue Multi-Context Retrieval and Enhanced Decoding Methods [PDF]
arXiv, 2022 Persona and Knowledge dual context open-domain chat is a novel dialogue generation task introduced recently. While Persona and Knowledge is each interesting context of open-domain dialogue, the combination of both has not been well studied. We tackle Persona-Knowledge identification and response generation tasks in this paper.
arxiv
, 2007 This is a preprint (author's original) version of an article published in The American Journal of Philology in 2007. The final version of this article may be found at http://muse.jhu.edu/journals/ajp/ (login may be required).
Uden, James
core +2 more sources
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Mapping Hsp104 interactions using cross‐linking mass spectrometry
FEBS Open Bio, EarlyView.This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal +3 more
wiley +1 more source
Hard To Stop: Image and Authorship in the Films of Steven Seagal [PDF]
, 2011 Little serious scholarly work has been done on the career of Steven Seagal which is surprising given his immense popularity in the early 1990s. In addition to suggesting more work be done on less traditional stars, this thesis asks what factors lead to ...
Van Esler, Michael W.
core
Beware the ‘Monological Imperatives’: Scholarly Writing for the Reader [PDF]
, 2007 This article describes principles of effective academic writing - offered not as edicts, but as guidelines - for legal scholars in particular. The overall focus is style, but the discussion begins with observations of format.
Magat, Joan A.
core +3 more sources