Results 81 to 90 of about 2,645,731 (390)
Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and BMI‐Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Prognostication of disease course and prediction of treatment response in multiple sclerosis is an unmet need. We compared the performance of serum neurofilament light chain Z scores (age‐ and BMI‐adjusted) with absolute concentrations for the prediction of response to disease‐modifying therapy.Maximilian Einsiedler, Aleksandra Maleska Maceski, Sofia Sandgren, Johanna Oechtering, Sabine Schaedelin, Lisa Hofer, Amar Zadic, Juan Francisco Vilchez Gomez, Lester Melie‐Garcia, Alessandro Cagol, Riccardo Galbusera, Sebastian Finkener, Patrice Lalive, Marjolaine Uginet, Stefanie Müller, Caroline Pot, Amandine Mathias, Renaud Du Pasquier, Robert Hoepner, Andrew Chan, Giulio Disanto, Chiara Zecca, Marcus D’Souza, Lars G. Hemkens, Tobias Derfuss, Özgür Yaldizli, Patrick Roth, Claudio Gobbi, David Brassat, Björn Tackenberg, Henrik Zetterberg, Tjalf Ziemssen, Heinz Wiendl, Klaus Berger, Marco Hermesdorf, Fredrik Piehl, Ludwig Kappos, Cristina Granziera, Ahmed Abdelhak, David Leppert, Eline A. J. Willemse, Pascal Benkert, Jens Kuhle, Swiss Multiple Sclerosis Cohort Study (SMSC) +43 morewiley +1 more sourceLong‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives
This ongoing, open‐label extension study is evaluating the long‐term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrophy (DMD). Methods
The recruited patients completed one of two prior clinical studies (one Phase 2 and one Phase 3 [EPIDYS ...Craig M. McDonald, Michela Guglieri, Dragana Vučinić, Gyula Acsadi, John F. Brandsema, Claudio Bruno, Erika L. Finanger, Amy Harper, Mercedes Lopez Lobato, Riccardo Masson, Nuria Muelas, Francina Munell, Yoram Nevo, Yann Péréon, Han Phan, Valeria A. Sansone, Mariacristina Scoto, Tracey Willis, Richard S. Finkel, Krista Vandenborne, Sara Cazzaniga, Silvia Montrasio, Federica Alessi, Paolo Bettica, Eugenio Mercuri, for the Givinostat Study 51 Investigators, the Cooperative International Neuromuscular Research Group (CINRG) Duchenne Natural History Study (DNHS) Investigators, the ImagingDMD Investigators, Enrico Bertini, Giacomo Pietro Comi, Eugenio Maria Mercuri, Giuseppe Vita, Sonia Messina, Claudio Bruno, Riccardo Masson, Valeria Sansone, Nathalie Goemans, Liesbeth De Waele, Laurent Servais, Teresa Gidaro, Odile Boespflug‐Tanguy, Yann Péréon, Jessika Johannsen, Astrid Blaschek, Ulrike Schara‐Schmidt, Erik Niks, Imelda de Groot, Saskia Houwen‐van Opstal, Andres Nascimento, Juan Jesus Vilchez, Nuria Muelas, Francina Munell, Marcos Madruga Garrido, Mercedes Lopez Lobato, Michaela Guglieri, Tracey Willis, Stefan Spinty, Daniel Hawcutt, Mariacristina Scoto, Jean K. Mah, Laura McAdam, Kathryn Selby, Katherine Mathews, Craig McDonald, Craig Zaidman, Barry Byrne, John Brandsema, Gyula Acsadi, Chamindra Laverty, Amy Harper, Erika Finanger, Han Phan, Yoram Nevo, Vedrana Milic Rasic, Dragana Vucinic +74 morewiley +1 more sourceThe Scholarship of Application
Academic Medicine, 2000 The scholarship of application encompasses a broad range of different types of scholarship in the sciences and humanities that involves translation of new knowledge to practical applications to solve problems of individuals and of society. The authors discuss this form of scholarship broadly, but focus on how it applies to patient-oriented research and David L. Coleman, Eugene D. Shapiroopenaire +4 more sourcesA community-sourced glossary of open scholarship terms
Nature Human Behaviour, 2022 S. Parsons, F. Azevedo, M. Elsherif, Samuel Guay, Owen N. Shahim, G. Govaart, E. Norris, Aoife O'Mahony, A. Parker, Ana Todorović, C. Pennington, Elias Garcia-Pelegrin, A. Lazić, Olly Robertson, S. Middleton, Beatrice Valentini, J. McCuaig, Bradley J. Baker, Elizabeth Collins, A. Fillon, T. Lonsdorf, Michele C. Lim, Norbert Vanek, Márton Kovács, T. Roettger, S. Rishi, Jacob F. Miranda, M. Jaquiery, S. Stewart, Valeria Agostini, Andrew J. Stewart, Kamil Izydorczak, Sarah Ashcroft-Jones, Helena Hartmann, Madeleine P. Ingham, Y. Yamada, Martin R. Vasilev, F. Děchtěrenko, Nihan Albayrak‐Aydemir, Yu-Fang Yang, LaPlume A. Annalise, J. Wolska, E. Henderson, M. Zaneva, Benjamin G. Farrar, Ross Mounce, T. Kalandadze, Wanyin Li, Q. Xiao, R. Ross, S. Yeung, Meng Liu, Micah Vandegrift, Z. Kekecs, M. Topor, Myriam A. Baum, E. A. Williams, Asma A. Assaneea, A. Bret, A. Cashin, N. Ballou, T. Dumbalska, B. Kern, Claire R Melia, Beatrix Arendt, G. H. Vineyard, Jade S. Pickering, T. Evans, C. Laverty, E. Woodward, David Moreau, Dominique G. Roche, E. M. Rinke, Graham Reid, Eduardo Garcia-Garzon, S. Verheyen, H. E. Kocalar, Ashley R Blake, J. P. Cockcroft, L. Micheli, Brice Beffara Bret, Zoe M. Flack, Barnabas Szaszi, M. Weinmann, Óscar Lecuona, Birgit Schmidt, W. Ngiam, A. B. Mendes, Shannon Francis, Brett J. Gall, Mariella Paul, C. Keating, Magdalena Grose-Hodge, James E. Bartlett, Bethan J. Iley, Lisa Spitzer, Madeleine Pownall, Christopher J. Graham, Tobias Wingen, Jenny Terry, C. M. F. Oliveira, Ryan A. Millager, K. Fox, Alaa Aldoh, Alexander Hart, O. V. D. Akker, Gilad Feldman, Dominik A. Kiersz, Christina Pomareda, Kai Krautter, Ali H. Al-Hoorie, B. Aczél +111 moresemanticscholar +1 more sourceDevelopment of a personalized visualization and analysis tool to improve clinical care in complex multisystem diseases with application to scleroderma
Arthritis Care &Research, Accepted Article.Background
In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently and at the point of care. Methods
We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of a scleroderma patient's ...Ji Soo Kim, John Scott, Lauren Fisher, Lauren N. Smith, Willie Stewart, Adrianne Woods, Rob Smithwright, Diane Koher, Parastoo Aslanbeik, Aalok B. Shah, Brad Tibbils, Samantha I. Pitts, Ayse P. Gurses, Yushi Yang, Ana‐Maria Orbai, Antony Rosen, Laura K. Hummers, Scott L. Zeger, Ami A. Shah +18 morewiley +1 more sourceCoalitions of scholarship [PDF]
Interventions, 2017 This article considers Bart Moore-Gilbert's unfinished work on Palestine and postcolonialism, which sought to demonstrate that contemporary Palestinian and Israeli writing challenges postcolonial s...openaire +5 more sources