Results 101 to 110 of about 11,113,502 (354)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Family-School Partnership in Supporting Level 4 Students at a Community Education and Training College

Central European Journal of Educational Research
Family-school partnership is essential for achieving quality school and academic performance to level 4 students at a Community Education and Training (CET) College.
Vumelani Mthobisi Shelembe, Mabatho Sedibe, Nonhlanhla Desiree Maseko   +2 more
doaj   +1 more source

Development of a WHO growth reference for school-aged children and adolescents.

Bulletin of the World Health Organization, 2007
M. de Onís, A. Onyango, E. Borghi, Amani Siyam, C. Nishida, J. Siekmann   +5 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The role of hope in bullying and cyberbullying prevention

Frontiers in Sociology
IntroductionResearch is clear that the cognitive-motivational internal asset of hope is significantly related to enhanced life satisfaction and psychological wellbeing.
Sameer Hinduja, Justin W. Patchin
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

ASSESSMENT OF INDIVIDUAL, BEHAVIORAL, AND ENVIRONMENTAL FACTORS INFLUENCING OVERWEIGHT/ OBESITY DEVELOPMENT IN CHILDREN AGED 10–14 YEARS

İstanbul Tıp Fakültesi Dergisi
Objective: Childhood obesity has emerged as a pressing global public health issue. This study aims to examine the influence of individual, behavioral, and environmental factors on student body mass index (BMI), thereby contributing to a deeper ...
Elnaz Karamelikli, Hülya Gül
doaj   +1 more source

School food standards in the UK: implementation and evaluation [PDF]

, 2013
Ashley Adamson, Suzanne Spence, Lowri Reed, Ruth Conway, A. W. Palmer, Eve Stewart, J. McBratney, Lynne Carter, Shirley Beattie, Michael Nelson   +9 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source