Results 121 to 130 of about 1,101,051 (314)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Challenges to using metal structures in the design of school buildings in hard-to-reach areas of Russia

Архитектон
The article analyzes the need for major repairs and construction of new schools in Russia, especially in northern and hard-to-reach regions. Space planning and engineering design principles for school design are defined.
Osipova Sofia V., Konovalova Elena A.
doaj   +1 more source

BUILDING CONDITION ASSESSMENT FOR SCHOOL BUILDING

PLANNING MALAYSIA
This research explores the multifaceted domain of Building Maintenance Management (BMM), focusing on issues, challenges, and assessment methodologies. A comprehensive review of literature spanning various academic disciplines and professional fields was conducted to synthesize existing knowledge and identify gaps in understanding.
Siti Fatimah Azzahra Mohd Nazri, Khairusy Syakirin Has-Yun Hashim, Mohamad Saiful Nizam Mohd Suhaimi   +2 more
openaire   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Building School Connectedness

International Journal of Education and Social Development
This study examines school connectedness as a multidimensional construct influencing student engagement, academic performance, and well-being. Through a synthesis of existing research, the paper identifies key strategies for fostering connectedness, including whole-school approaches, relational support systems, and inclusive policies.
openaire   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

SCHOOL BUILDING PLANNING. MAIN TYPES OF SYSTEMS (PLANS) OF SCHOOL BUILDINGS

World Science, 2019
How to Design School Buildings? Student(s), their number and age have the gratest impact on the school buildings;• To plan a school well, it must first be clear which age groups of students it will be for;• How many students will be there in each age group;• How many classes in each grade will be in the building.Following the study
openaire   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Sustaining Cultural Heritage at UNH [PDF]

, 2015
Building a new road? A cell phone tower? A pipeline? A new government building? Building anything with federal funds or on federal property requires that one must conduct a review of the impact of the project on tangible cultural resources, which ...
Howey, Meghan L.
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source