Results 81 to 90 of about 1,408,061 (267)

“It’s like going through life at a mediocre level”: a qualitative study of the meaning and impact of fatigue in children and young people with sickle cell disease

BMC Pediatrics
Background Fatigue is increasingly recognised as a prevalent and debilitating symptom for children and young people (CYP) with long-term conditions (LTCs), significantly affecting their family, social and educational participation. In sickle cell disease
Brenda Agyeiwaa Poku, Karl Michael Atkin, John David Grainger, Iyamide Thomas, Rachael Oshinbolu, Abubakar Mohammed, Edith Kyewalyanga, Susan Kirk   +7 more
doaj   +1 more source

Savoirs autochtones et utopie démocratique : résister à l’urbanisation par l’expérience scolaire et l’enracinement territorial

IdeAs
In this article, I present the methodological strategies implemented in teaching-learning to highlight the indigenous environment as a form of resistance to rampant urbanization in Florianópolis, Brazil.
Clara Rosana Chagas Paraboa
doaj   +1 more source

At-Risk Brand Relationships and Threats to the Bottom Line

GfK Marketing Intelligence Review, 2018
Like a stock portfolio, each relationship type offers a brand higher or lower growth opportunities and risks. The type of relationship is particularly relevant in brand crisis events.
Hupp Oliver, Robbins David, Fournier Susan   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Challenges of Inclusion: A Population‐Based Interview Study of Long Covid

Health Expectations
Introduction People with long Covid report a wide range of symptoms and inconsistent responses when seeking clinical diagnosis and support. Much of the qualitative research on long Covid has been based on people attending specialist clinical services or ...
Emily Cooper, Adam Lound, Kathryn Jones, Jane Bruton, Sophie Day, Christina J. Atchison, Caroline Eccles, Alex Piper, Graham S. Cooke, Marc Chadeau‐Hyam, Paul Elliott, Helen Ward   +11 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Influence of rural clinical school experience and rural origin on practising in rural communities five and eight years after graduation. [PDF]

Med J Aust, 2022
Seal AN, Playford D, McGrail MR, Fuller L, Allen PL, Burrows JM, Wright JR, Bain-Donohue S, Garne D, Major LG, Luscombe GM.   +10 more
europepmc   +1 more source

Patient-reported outcome measures for primary hyperparathyroidism: a systematic review of measurement properties

Health and Quality of Life Outcomes
Background The quality of patient-reported outcome measures (PROMs) used to assess the outcomes of primary hyperparathyroidism (PHPT), a common endocrine disorder that can negatively affect patients’ health-related quality of life due to chronic symptoms,
George Liang, Manraj N. Kaur, Carrie G. Wade, Maria O. Edelen, David W. Bates, Andrea L. Pusic, Jason B. Liu   +6 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

The Effect of COVID-19 on the Medical School Experience, Specialty Selection, and Career Choice: A Qualitative Study. [PDF]

J Surg Educ, 2022
Krier CR, Quinn K, Kaljo K, Farkas AH, Ellinas EH.   +4 more
europepmc   +1 more source