Results 141 to 150 of about 1,341,174 (217)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Beyond additive genetic effects: Explaining family resemblance in school performance across millions of pairs of Norwegian relatives. [PDF]

Proc Natl Acad Sci U S A
Eftedal NH, Eilertsen EM, Sunde HF, Kleppestø TH, Ystrom E, Czajkowski NO.   +5 more
europepmc   +1 more source

Risk of impaired school performance in children hospitalized with concussion: a population-based matched cohort study. [PDF]

Concussion, 2023
Lystad RP, McMaugh A, Herkes G, Browne G, Badgery-Parker T, Cameron CM, Mitchell RJ.   +6 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Parental mental disorders and school performance among non-immigrant and second-generation immigrant children in Sweden. [PDF]

J Migr Health
Okuyama K, Lönn SL, Khoshnood AM, Sundquist J, Sundquist K.   +4 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Premorbid school performance trajectories in patients with treatment-resistant schizophrenia prescribed clozapine in the public health system in Chile: a case-control study, 2007-2020. [PDF]

Psychol Med
Conejeros-Pavez J, Vasquez J, Diaz C, Mena C, Undurraga J, Gonzalez-Valderrama A, Claro S, Undurraga EA, Crossley NA.   +8 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

School Performance of Preterm-Born Children After Intraventricular Hemorrhage.

JAMA Netw Open
Rees P, Dronavalli M, Carter B, Dickson M, Green C, Lawler K, Lee E, Uebel H, Gale C, Gale C, Oei JL.   +10 more
europepmc   +1 more source

Impact of early childhood infection on child development and school performance: a population-based study. [PDF]

J Epidemiol Community Health
He WQ, Moore HC, Miller JE, Burgner DP, Swann O, Lain SJ, Nassar N.   +6 more
europepmc   +1 more source