Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Importance of pre-school science education
SHS Web of Conferences, 2017 Considering this aspect of the study, the objective of the study is determining the importance of science education in pre-school period. In this research, two open-ended questions were asked to the prospective teachers. In these questions, the focus was
Kaçan Sibel Demir, Çelikler Dilek
doaj +1 more source
U.S. and Finnish high school science engagement during the COVID-19 pandemic. [PDF]
Int J Psychol, 2022 Maestrales S +8 more
europepmc +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Teachers' perceptions of Brandon's Matrix as a framework for the teaching and assessment of scientific methods in school science. [PDF]
Res Sci Educ, 2023 Cullinane A +3 more
europepmc +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Science, Culture and Citizenship: Cross-Cultural Science Education
Revista Brasileira de Pesquisa em Educação em Ciências, 2011 My paper has three purposes: (1) to explore an alternative to the conventional mono-cultural science curriculum in schools narrowly defined by Eurocentric science; (2) to consider the benefits that accrue from a school science curriculum that recognizes ...
Glen S. Aikenhead, Kenio E. C. Lima
doaj
Examining teachers' self-regulation practice in secondary school science teaching: the case of South Gondar Zone, Ethiopia. [PDF]
Heliyon, 2021 Mengistnew M, Sahile A, Asrat D.
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source